BRD-A19248578_L5288-1MG_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-A19248578_L5288-1MG_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
ADGRL1 adhesion G protein-coupled receptor L1
ANGPTL2 angiopoietin-like 2
ASPN asporin
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CARKD carbohydrate kinase domain containing
CCDC69 coiled-coil domain containing 69
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
COL15A1 collagen, type XV, alpha 1
CTSB cathepsin B
CTSK cathepsin K
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FUCA1 fucosidase, alpha-L- 1, tissue
GAS1 growth arrest-specific 1
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MXI1 MAX interactor 1, dimerization protein
OLFML2B olfactomedin-like 2B
PDE8A phosphodiesterase 8A
PDE8B phosphodiesterase 8B
PDGFRL platelet-derived growth factor receptor-like
PLXDC1 plexin domain containing 1
PLXNC1 plexin C1
POR P450 (cytochrome) oxidoreductase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB31 RAB31, member RAS oncogene family
RGS5 regulator of G-protein signaling 5
RXRA retinoid X receptor, alpha
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
VGLL4 vestigial-like family member 4
ZCCHC14 zinc finger, CCHC domain containing 14

decreased expression

Symbol Name
ANXA3 annexin A3
ARSJ arylsulfatase family, member J
ASNS asparagine synthetase (glutamine-hydrolyzing)
AXL AXL receptor tyrosine kinase
BIRC5 baculoviral IAP repeat containing 5
CA12 carbonic anhydrase XII
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
CD24 CD24 molecule
CD69 CD69 molecule
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEP55 centrosomal protein 55kDa
CHMP4A charged multivesicular body protein 4A
CLIC4 chloride intracellular channel 4
COL8A1 collagen, type VIII, alpha 1
CORO1C coronin, actin binding protein, 1C
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
GARS glycyl-tRNA synthetase
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
HMGB2 high mobility group box 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT14 keratin 14, type I
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
LTBP1 latent transforming growth factor beta binding protein 1
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MRPS16 mitochondrial ribosomal protein S16
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PFKP phosphofructokinase, platelet
PGM3 phosphoglucomutase 3
PHGDH phosphoglycerate dehydrogenase
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS23 protease, serine, 23
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTX3 pentraxin 3, long
PXDC1 PX domain containing 1
RGS4 regulator of G-protein signaling 4
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A10 S100 calcium binding protein A10
S100A6 S100 calcium binding protein A6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMS spermine synthase
STC2 stanniocalcin 2
TAGLN transgelin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TSPAN13 tetraspanin 13
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C