BRD-A19248578_L5288-1MG_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-A19248578_L5288-1MG_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AMDHD2 amidohydrolase domain containing 2
ARG2 arginase 2
BAMBI BMP and activin membrane-bound inhibitor
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSA cathepsin A
CTSV cathepsin V
FAM117A family with sequence similarity 117, member A
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FRY furry homolog (Drosophila)
GNS glucosamine (N-acetyl)-6-sulfatase
GRN granulin
GSDMB gasdermin B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDAC5 histone deacetylase 5
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
JAG1 jagged 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MBNL1 muscleblind-like splicing regulator 1
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NOSIP nitric oxide synthase interacting protein
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PLA2G15 phospholipase A2, group XV
PLA2G16 phospholipase A2, group XVI
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RBPMS RNA binding protein with multiple splicing
RSRP1 arginine/serine-rich protein 1
SCPEP1 serine carboxypeptidase 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX4 SRY (sex determining region Y)-box 4
TNS1 tensin 1
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VGLL4 vestigial-like family member 4
WDTC1 WD and tetratricopeptide repeats 1
WFDC1 WAP four-disulfide core domain 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARPP19 cAMP-regulated phosphoprotein, 19kDa
AXL AXL receptor tyrosine kinase
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CHI3L2 chitinase 3-like 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXOSC2 exosome component 2
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP16 NOP16 nucleolar protein
PIR pirin (iron-binding nuclear protein)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPIF peptidylprolyl isomerase F
RDX radixin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TIPIN TIMELESS interacting protein
UPK1B uroplakin 1B
WDR43 WD repeat domain 43