BRD-A19248578_L5288-1MG_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-A19248578_L5288-1MG_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGR2 anterior gradient 2
APOD apolipoprotein D
AREG amphiregulin
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
CA12 carbonic anhydrase XII
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CFB complement factor B
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CPM carboxypeptidase M
CTSA cathepsin A
CTSB cathepsin B
DUSP4 dual specificity phosphatase 4
ENO2 enolase 2 (gamma, neuronal)
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV5 ets variant 5
FHOD3 formin homology 2 domain containing 3
FOXO4 forkhead box O4
FZD5 frizzled class receptor 5
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GRN granulin
HEXB hexosaminidase B (beta polypeptide)
IFITM1 interferon induced transmembrane protein 1
IGFBP6 insulin-like growth factor binding protein 6
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KLF5 Kruppel-like factor 5 (intestinal)
LAMA3 laminin, alpha 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MFSD1 major facilitator superfamily domain containing 1
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MLPH melanophilin
MTMR11 myotubularin related protein 11
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
PLCB4 phospholipase C, beta 4
PPAP2B phosphatidic acid phosphatase type 2B
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOQ ras homolog family member Q
SFRP1 secreted frizzled-related protein 1
SLC22A18 solute carrier family 22, member 18
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC46A3 solute carrier family 46, member 3
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TFF1 trefoil factor 1
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNS1 tensin 1
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
XBP1 X-box binding protein 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3ORF14 chromosome 3 open reading frame 14
CCNB2 cyclin B2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPN centromere protein N
CENPU centromere protein U
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL3A1 collagen, type III, alpha 1
COMMD8 COMM domain containing 8
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
FANCI Fanconi anemia, complementation group I
GEMIN2 gem (nuclear organelle) associated protein 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
HOPX HOP homeobox
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MT1E metallothionein 1E
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PEA15 phosphoprotein enriched in astrocytes 15
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
RAD51 RAD51 recombinase
RBP1 retinol binding protein 1, cellular
RCC1 regulator of chromosome condensation 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SDC2 syndecan 2
SHCBP1 SHC SH2-domain binding protein 1
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TK1 thymidine kinase 1, soluble
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TXNDC9 thioredoxin domain containing 9