BRD-A19195498_TRIMIPRAMINE MALEATE_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

189 genes differentially expressed following the BRD-A19195498_TRIMIPRAMINE MALEATE_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
AQP9 aquaporin 9
ARG1 arginase 1
ARG2 arginase 2
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C14ORF132 chromosome 14 open reading frame 132
CA4 carbonic anhydrase IV
CALML3 calmodulin-like 3
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN8 claudin 8
CLIC3 chloride intracellular channel 3
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DAXX death-domain associated protein
DCN decorin
DENND1B DENN/MADD domain containing 1B
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EZR ezrin
FAM69A family with sequence similarity 69, member A
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FLT1 fms-related tyrosine kinase 1
FRZB frizzled-related protein
FXYD6 FXYD domain containing ion transport regulator 6
FZD1 frizzled class receptor 1
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
GSTA1 glutathione S-transferase alpha 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA2 heat shock 70kDa protein 2
HSPA4 heat shock 70kDa protein 4
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL17RB interleukin 17 receptor B
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
INSM1 insulinoma-associated 1
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITM2C integral membrane protein 2C
IVNS1ABP influenza virus NS1A binding protein
JCHAIN joining chain of multimeric IgA and IgM
KDR kinase insert domain receptor
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LPCAT1 lysophosphatidylcholine acyltransferase 1
MATN2 matrilin 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
MLPH melanophilin
MMP9 matrix metallopeptidase 9
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
NCF2 neutrophil cytosolic factor 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZK1IP1 PDZK1 interacting protein 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
RAB21 RAB21, member RAS oncogene family
RAI14 retinoic acid induced 14
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPON2 spondin 2, extracellular matrix protein
SRGN serglycin
SST somatostatin
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SYNGR1 synaptogyrin 1
TACSTD2 tumor-associated calcium signal transducer 2
TBXA2R thromboxane A2 receptor
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
VEGFA vascular endothelial growth factor A
WFDC1 WAP four-disulfide core domain 1
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACACB acetyl-CoA carboxylase beta
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AXL AXL receptor tyrosine kinase
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNF cyclin F
CENPF centromere protein F, 350/400kDa
CHL1 cell adhesion molecule L1-like
CTSZ cathepsin Z
DAPK1 death-associated protein kinase 1
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FAM171A1 family with sequence similarity 171, member A1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
H1F0 H1 histone family, member 0
HOXB7 homeobox B7
HOXC6 homeobox C6
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
KIF14 kinesin family member 14
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTBP3 latent transforming growth factor beta binding protein 3
MED1 mediator complex subunit 1
NAV3 neuron navigator 3
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NFIB nuclear factor I/B
NGRN neugrin, neurite outgrowth associated
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCDH9 protocadherin 9
PITRM1 pitrilysin metallopeptidase 1
PLAC8 placenta-specific 8
PNMA1 paraneoplastic Ma antigen 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RDX radixin
RPS26 ribosomal protein S26
SACS sacsin molecular chaperone
SATB2 SATB homeobox 2
SELL selectin L
SEPW1 selenoprotein W, 1
SMAD1 SMAD family member 1
SRSF7 serine/arginine-rich splicing factor 7
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPAN8 tetraspanin 8
TYRP1 tyrosinase-related protein 1
UBE2S ubiquitin-conjugating enzyme E2S
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta