BRD-A19195498_TRIMIPRAMINE MALEATE_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-A19195498_TRIMIPRAMINE MALEATE_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
COL10A1 collagen, type X, alpha 1
CTSH cathepsin H
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DMBT1 deleted in malignant brain tumors 1
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
EBP emopamil binding protein (sterol isomerase)
EDNRA endothelin receptor type A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELOVL6 ELOVL fatty acid elongase 6
EPS8 epidermal growth factor receptor pathway substrate 8
ETV1 ets variant 1
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FAP fibroblast activation protein, alpha
FBN2 fibrillin 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGFR1 fibroblast growth factor receptor 1
FGFR4 fibroblast growth factor receptor 4
G0S2 G0/G1 switch 2
G6PD glucose-6-phosphate dehydrogenase
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GNPDA1 glucosamine-6-phosphate deaminase 1
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITGB5 integrin, beta 5
KDM5D lysine (K)-specific demethylase 5D
KYNU kynureninase
LAMA2 laminin, alpha 2
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
METTL7A methyltransferase like 7A
MMP11 matrix metallopeptidase 11
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
NEU1 sialidase 1 (lysosomal sialidase)
NSDHL NAD(P) dependent steroid dehydrogenase-like
PLXNC1 plexin C1
PPARD peroxisome proliferator-activated receptor delta
PTPRK protein tyrosine phosphatase, receptor type, K
QPCT glutaminyl-peptide cyclotransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SC5D sterol-C5-desaturase
SIRPA signal-regulatory protein alpha
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
TMEM97 transmembrane protein 97
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VCAN versican
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
BIRC3 baculoviral IAP repeat containing 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
CCL2 chemokine (C-C motif) ligand 2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFLAR CASP8 and FADD-like apoptosis regulator
CLIC3 chloride intracellular channel 3
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CYCS cytochrome c, somatic
DCT dopachrome tautomerase
DLC1 DLC1 Rho GTPase activating protein
DSC2 desmocollin 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FSD1 fibronectin type III and SPRY domain containing 1
FXYD3 FXYD domain containing ion transport regulator 3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLIPR1 GLI pathogenesis-related 1
HIST1H1C histone cluster 1, H1c
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KLF4 Kruppel-like factor 4 (gut)
LOX lysyl oxidase
MAOA monoamine oxidase A
MYBPC1 myosin binding protein C, slow type
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
RGS5 regulator of G-protein signaling 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC35F2 solute carrier family 35, member F2
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TCF4 transcription factor 4
TMSB15A thymosin beta 15a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XIST X inactive specific transcript (non-protein coding)