BRD-A19037878_trichostatin A_WSUDLCL2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-A19037878_trichostatin A_WSUDLCL2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADCY9 adenylate cyclase 9
ADD3 adducin 3 (gamma)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ANXA2 annexin A2
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
BAX BCL2-associated X protein
C2CD2 C2 calcium-dependent domain containing 2
CCL8 chemokine (C-C motif) ligand 8
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLU clusterin
CRABP2 cellular retinoic acid binding protein 2
CREG1 cellular repressor of E1A-stimulated genes 1
CST1 cystatin SN
CXADR coxsackie virus and adenovirus receptor
CYB5R1 cytochrome b5 reductase 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DLK1 delta-like 1 homolog (Drosophila)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM129A family with sequence similarity 129, member A
FAM171A1 family with sequence similarity 171, member A1
FAM69A family with sequence similarity 69, member A
FGFR3 fibroblast growth factor receptor 3
FMO2 flavin containing monooxygenase 2 (non-functional)
GADD45B growth arrest and DNA-damage-inducible, beta
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPC4 glypican 4
HBB hemoglobin, beta
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLA-C major histocompatibility complex, class I, C
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IQCG IQ motif containing G
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
KCTD5 potassium channel tetramerization domain containing 5
L1CAM L1 cell adhesion molecule
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGMN legumain
LRP4 low density lipoprotein receptor-related protein 4
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MLF1 myeloid leukemia factor 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
NEU1 sialidase 1 (lysosomal sialidase)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOSIP nitric oxide synthase interacting protein
NQO2 NAD(P)H dehydrogenase, quinone 2
NSFL1C NSFL1 (p97) cofactor (p47)
NUPR1 nuclear protein, transcriptional regulator, 1
OASL 2'-5'-oligoadenylate synthetase-like
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G15 phospholipase A2, group XV
PLIN2 perilipin 2
POLB polymerase (DNA directed), beta
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRSS2 protease, serine, 2 (trypsin 2)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSAD2 radical S-adenosyl methionine domain containing 2
SDC3 syndecan 3
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SNN stannin
TSPAN6 tetraspanin 6
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
USP18 ubiquitin specific peptidase 18
VAV3 vav 3 guanine nucleotide exchange factor
VWA5A von Willebrand factor A domain containing 5A
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARID1A AT rich interactive domain 1A (SWI-like)
ATF5 activating transcription factor 5
BCL2 B-cell CLL/lymphoma 2
BIRC3 baculoviral IAP repeat containing 3
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CCL20 chemokine (C-C motif) ligand 20
CDC42 cell division cycle 42
CHMP4A charged multivesicular body protein 4A
COL1A1 collagen, type I, alpha 1
COL4A6 collagen, type IV, alpha 6
COL5A2 collagen, type V, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSK c-src tyrosine kinase
CSTA cystatin A (stefin A)
DHRS7 dehydrogenase/reductase (SDR family) member 7
DICER1 dicer 1, ribonuclease type III
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ELF1 E74-like factor 1 (ets domain transcription factor)
EMP3 epithelial membrane protein 3
EVI2B ecotropic viral integration site 2B
EVL Enah/Vasp-like
FAM57A family with sequence similarity 57, member A
GAS2 growth arrest-specific 2
GPX2 glutathione peroxidase 2
GRB14 growth factor receptor-bound protein 14
HHEX hematopoietically expressed homeobox
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA10 homeobox A10
IGFBP1 insulin-like growth factor binding protein 1
IGHM immunoglobulin heavy constant mu
IRAK1 interleukin-1 receptor-associated kinase 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KYNU kynureninase
LMO2 LIM domain only 2 (rhombotin-like 1)
MFAP5 microfibrillar associated protein 5
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PIP prolactin-induced protein
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
POU2AF1 POU class 2 associating factor 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPL37A ribosomal protein L37a
RRM2 ribonucleotide reductase M2
SEH1L SEH1-like (S. cerevisiae)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOD2 superoxide dismutase 2, mitochondrial
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAP1 signal transducing adaptor family member 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STXBP2 syntaxin binding protein 2
TAGLN transgelin
TBL1X transducin (beta)-like 1X-linked
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMPO thymopoietin
TNIP1 TNFAIP3 interacting protein 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1
WIPF1 WAS/WASL interacting protein family, member 1
WTAP Wilms tumor 1 associated protein
ZBTB38 zinc finger and BTB domain containing 38
ZMIZ1 zinc finger, MIZ-type containing 1