BRD-A19037878_trichostatin A_U937_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

252 genes differentially expressed following the BRD-A19037878_trichostatin A_U937_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACAA1 acetyl-CoA acyltransferase 1
ACOT7 acyl-CoA thioesterase 7
ADAM28 ADAM metallopeptidase domain 28
ADD3 adducin 3 (gamma)
ADRB2 adrenoceptor beta 2, surface
AHCYL2 adenosylhomocysteinase-like 2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCL3 B-cell CLL/lymphoma 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCDC28A coiled-coil domain containing 28A
CCNA1 cyclin A1
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CPNE3 copine III
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYB5A cytochrome b5 type A (microsomal)
CYB5R1 cytochrome b5 reductase 1
CYB5R3 cytochrome b5 reductase 3
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSE dermatan sulfate epimerase
DSTN destrin (actin depolymerizing factor)
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EFNB2 ephrin-B2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM117A family with sequence similarity 117, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
G6PD glucose-6-phosphate dehydrogenase
GLRX glutaredoxin (thioltransferase)
GOLGA7 golgin A7
GRN granulin
H1F0 H1 histone family, member 0
HIST1H1C histone cluster 1, H1c
HLTF helicase-like transcription factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IGFBP5 insulin-like growth factor binding protein 5
IL1B interleukin 1, beta
IQCG IQ motif containing G
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCTD12 potassium channel tetramerization domain containing 12
LTA4H leukotriene A4 hydrolase
MAP7 microtubule-associated protein 7
MAPK9 mitogen-activated protein kinase 9
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
MGST3 microsomal glutathione S-transferase 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLF1 myeloid leukemia factor 1
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
MXRA7 matrix-remodelling associated 7
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NME7 NME/NM23 family member 7
NOSIP nitric oxide synthase interacting protein
NPC2 Niemann-Pick disease, type C2
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OPTN optineurin
OSTM1 osteopetrosis associated transmembrane protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PECR peroxisomal trans-2-enoyl-CoA reductase
PEG10 paternally expressed 10
PEPD peptidase D
PFKM phosphofructokinase, muscle
PLA2G15 phospholipase A2, group XV
PLA2G16 phospholipase A2, group XVI
PLAU plasminogen activator, urokinase
PLD3 phospholipase D family, member 3
PLS1 plastin 1
POLB polymerase (DNA directed), beta
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POR P450 (cytochrome) oxidoreductase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS3 protease, serine, 3
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RRAGA Ras-related GTP binding A
RRAGC Ras-related GTP binding C
RWDD1 RWD domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SELL selectin L
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SESN1 sestrin 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC46A3 solute carrier family 46, member 3
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SNX3 sorting nexin 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON1 spondin 1, extracellular matrix protein
SPTAN1 spectrin, alpha, non-erythrocytic 1
SQSTM1 sequestosome 1
TBPL1 TBP-like 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM7SF2 transmembrane 7 superfamily member 2
TMEM41B transmembrane protein 41B
TREM1 triggering receptor expressed on myeloid cells 1
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
VAMP3 vesicle-associated membrane protein 3
VCL vinculin
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ADNP activity-dependent neuroprotector homeobox
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AGTR1 angiotensin II receptor, type 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOLD1 apolipoprotein L domain containing 1
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
AZU1 azurocidin 1
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
C6ORF62 chromosome 6 open reading frame 62
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CES1 carboxylesterase 1
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CX3CL1 chemokine (C-X3-C motif) ligand 1
DENND2D DENN/MADD domain containing 2D
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
ELANE elastase, neutrophil expressed
ELF1 E74-like factor 1 (ets domain transcription factor)
EMG1 EMG1 N1-specific pseudouridine methyltransferase
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FGF13 fibroblast growth factor 13
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FXN frataxin
FXYD5 FXYD domain containing ion transport regulator 5
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GEMIN4 gem (nuclear organelle) associated protein 4
GPNMB glycoprotein (transmembrane) nmb
HAPLN1 hyaluronan and proteoglycan link protein 1
HMGB2 high mobility group box 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA10 homeobox A10
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IGFBP7 insulin-like growth factor binding protein 7
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
M6PR mannose-6-phosphate receptor (cation dependent)
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MPO myeloperoxidase
MSMB microseminoprotein, beta-
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NMI N-myc (and STAT) interactor
NR2F2 nuclear receptor subfamily 2, group F, member 2
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
PKP4 plakophilin 4
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PPAP2C phosphatidic acid phosphatase type 2C
PRTN3 proteinase 3
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAD23B RAD23 homolog B (S. cerevisiae)
REPIN1 replication initiator 1
RGS5 regulator of G-protein signaling 5
SET SET nuclear proto-oncogene
SLC43A3 solute carrier family 43, member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMYD2 SET and MYND domain containing 2
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY2 sprouty homolog 2 (Drosophila)
STAG2 stromal antigen 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TF transferrin
TFF1 trefoil factor 1
TOR1A torsin family 1, member A (torsin A)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VEGFA vascular endothelial growth factor A
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
WIPF1 WAS/WASL interacting protein family, member 1
XPO7 exportin 7
XPOT exportin, tRNA
ZFP36L2 ZFP36 ring finger protein-like 2