BRD-A19037878_trichostatin A_TYKNU_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-A19037878_trichostatin A_TYKNU_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ABHD3 abhydrolase domain containing 3
ADCK3 aarF domain containing kinase 3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADRB2 adrenoceptor beta 2, surface
AHCYL2 adenosylhomocysteinase-like 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANKRD46 ankyrin repeat domain 46
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLCA1 chloride channel accessory 1
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CSRP1 cysteine and glycine-rich protein 1
CYB5A cytochrome b5 type A (microsomal)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DES desmin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FADS3 fatty acid desaturase 3
FBXL12 F-box and leucine-rich repeat protein 12
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
GSDMB gasdermin B
HEBP1 heme binding protein 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
INSR insulin receptor
ITM2C integral membrane protein 2C
KIAA0226L KIAA0226-like
KRT20 keratin 20, type I
LTB lymphotoxin beta (TNF superfamily, member 3)
MAOA monoamine oxidase A
MB myoglobin
METRN meteorin, glial cell differentiation regulator
MSMO1 methylsterol monooxygenase 1
MYBPC1 myosin binding protein C, slow type
NAMPT nicotinamide phosphoribosyltransferase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH9 protocadherin 9
PEG10 paternally expressed 10
PFKM phosphofructokinase, muscle
PLA2G15 phospholipase A2, group XV
POLB polymerase (DNA directed), beta
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PTPRE protein tyrosine phosphatase, receptor type, E
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGS13 regulator of G-protein signaling 13
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A14 S100 calcium binding protein A14
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC46A3 solute carrier family 46, member 3
SNN stannin
SPTSSA serine palmitoyltransferase, small subunit A
STXBP2 syntaxin binding protein 2
TGFA transforming growth factor, alpha
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM14A transmembrane protein 14A
TOB1 transducer of ERBB2, 1
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
WBP1L WW domain binding protein 1-like

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4A ADP-ribosylation factor-like 4A
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
CDC20 cell division cycle 20
CKAP4 cytoskeleton-associated protein 4
CSK c-src tyrosine kinase
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
DAXX death-domain associated protein
DCLK1 doublecortin-like kinase 1
DCTD dCMP deaminase
DEGS1 delta(4)-desaturase, sphingolipid 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EREG epiregulin
F5 coagulation factor V (proaccelerin, labile factor)
FAM57A family with sequence similarity 57, member A
FBN1 fibrillin 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GABPB1 GA binding protein transcription factor, beta subunit 1
GANAB glucosidase, alpha; neutral AB
GPR171 G protein-coupled receptor 171
GSTO1 glutathione S-transferase omega 1
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXB6 homeobox B6
HOXB7 homeobox B7
IDO1 indoleamine 2,3-dioxygenase 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHD immunoglobulin heavy constant delta
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KPNB1 karyopherin (importin) beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LY6E lymphocyte antigen 6 complex, locus E
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MRPS18B mitochondrial ribosomal protein S18B
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS3 nitric oxide synthase 3 (endothelial cell)
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
OXA1L oxidase (cytochrome c) assembly 1-like
PARVB parvin, beta
PIR pirin (iron-binding nuclear protein)
PLAGL1 pleiomorphic adenoma gene-like 1
PROM1 prominin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
QPCT glutaminyl-peptide cyclotransferase
RBM34 RNA binding motif protein 34
RBMX RNA binding motif protein, X-linked
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPP25 ribonuclease P/MRP 25kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
SSFA2 sperm specific antigen 2
STEAP3 STEAP family member 3, metalloreductase
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
VCAN versican
XIST X inactive specific transcript (non-protein coding)
ZMYND8 zinc finger, MYND-type containing 8