BRD-A19037878_trichostatin A_SW948_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-A19037878_trichostatin A_SW948_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP12 A kinase (PRKA) anchor protein 12
ARHGAP29 Rho GTPase activating protein 29
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CCNG2 cyclin G2
CGA glycoprotein hormones, alpha polypeptide
CRABP1 cellular retinoic acid binding protein 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
FAM107A family with sequence similarity 107, member A
FAM117A family with sequence similarity 117, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GALC galactosylceramidase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HIST1H1C histone cluster 1, H1c
HLTF helicase-like transcription factor
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HYOU1 hypoxia up-regulated 1
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGMN legumain
MAGEB2 melanoma antigen family B2
MLF1 myeloid leukemia factor 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OAT ornithine aminotransferase
OLFM1 olfactomedin 1
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PCDH9 protocadherin 9
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG3 paternally expressed 3
PLA2G15 phospholipase A2, group XV
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RGS2 regulator of G-protein signaling 2
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SIK1 salt-inducible kinase 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SRPX sushi-repeat containing protein, X-linked
TKTL1 transketolase-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VWA5A von Willebrand factor A domain containing 5A
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
BMP4 bone morphogenetic protein 4
CDC25A cell division cycle 25A
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CSK c-src tyrosine kinase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DCTD dCMP deaminase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEK DEK proto-oncogene
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FUS FUS RNA binding protein
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPX2 glutathione peroxidase 2
GTF2IRD1 GTF2I repeat domain containing 1
HBEGF heparin-binding EGF-like growth factor
HDGF hepatoma-derived growth factor
HMGA2 high mobility group AT-hook 2
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IRAK1 interleukin-1 receptor-associated kinase 1
KEAP1 kelch-like ECH-associated protein 1
LCN2 lipocalin 2
LMNB1 lamin B1
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PPAP2C phosphatidic acid phosphatase type 2C
RAD23B RAD23 homolog B (S. cerevisiae)
RCC1 regulator of chromosome condensation 1
S100A8 S100 calcium binding protein A8
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAGP small cell adhesion glycoprotein
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYPL1 synaptophysin-like 1
TCERG1 transcription elongation regulator 1
TRIM14 tripartite motif containing 14
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
WDR82 WD repeat domain 82
ZNF706 zinc finger protein 706