BRD-A19037878_trichostatin A_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

266 genes differentially expressed following the BRD-A19037878_trichostatin A_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADAM9 ADAM metallopeptidase domain 9
ALOX15B arachidonate 15-lipoxygenase, type B
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATF3 activating transcription factor 3
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIK BCL2-interacting killer (apoptosis-inducing)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CD14 CD14 molecule
CD164 CD164 molecule, sialomucin
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIB1 calcium and integrin binding 1 (calmyrin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CLDN3 claudin 3
COL11A1 collagen, type XI, alpha 1
CORO1A coronin, actin binding protein, 1A
CREB3L2 cAMP responsive element binding protein 3-like 2
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DCTN3 dynactin 3 (p22)
DGKA diacylglycerol kinase, alpha 80kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP10 dual specificity phosphatase 10
EDN1 endothelin 1
EIF5A eukaryotic translation initiation factor 5A
ENAH enabled homolog (Drosophila)
EPAS1 endothelial PAS domain protein 1
FAM117A family with sequence similarity 117, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FN1 fibronectin 1
FOXO4 forkhead box O4
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GAS6 growth arrest-specific 6
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRHPR glyoxylate reductase/hydroxypyruvate reductase
GSDMB gasdermin B
GUK1 guanylate kinase 1
H2AFV H2A histone family, member V
HEPH hephaestin
HIST1H1C histone cluster 1, H1c
HMG20B high mobility group 20B
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IL17RB interleukin 17 receptor B
INHBA inhibin, beta A
IPO13 importin 13
IQGAP1 IQ motif containing GTPase activating protein 1
ISG15 ISG15 ubiquitin-like modifier
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KLK5 kallikrein-related peptidase 5
KRT7 keratin 7, type II
LPIN1 lipin 1
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LYPD1 LY6/PLAUR domain containing 1
MGST3 microsomal glutathione S-transferase 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MSRB1 methionine sulfoxide reductase B1
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1X metallothionein 1X
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NOSIP nitric oxide synthase interacting protein
NOTCH1 notch 1
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK5 proprotein convertase subtilisin/kexin type 5
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PON3 paraoxonase 3
PRKCD protein kinase C, delta
PROM1 prominin 1
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPRF protein tyrosine phosphatase, receptor type, F
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS10 regulator of G-protein signaling 10
RNF130 ring finger protein 130
ROGDI rogdi homolog (Drosophila)
SCGB1D2 secretoglobin, family 1D, member 2
SCPEP1 serine carboxypeptidase 1
SDC1 syndecan 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNN stannin
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLE4 transducin-like enhancer of split 4
TMSB15A thymosin beta 15a
TOB1 transducer of ERBB2, 1
TRIM2 tripartite motif containing 2
TUBA1A tubulin, alpha 1a
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP3 vesicle-associated membrane protein 3
VCL vinculin
VNN1 vanin 1
WIPF2 WAS/WASL interacting protein family, member 2
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARL4A ADP-ribosylation factor-like 4A
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
ATP13A3 ATPase type 13A3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CBFB core-binding factor, beta subunit
CD24 CD24 molecule
CETN3 centrin, EF-hand protein, 3
CHRDL1 chordin-like 1
CRYAB crystallin, alpha B
CST7 cystatin F (leukocystatin)
CTBP1 C-terminal binding protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
DCLK1 doublecortin-like kinase 1
DCTD dCMP deaminase
DEFB4A defensin, beta 4A
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF4B eukaryotic translation initiation factor 4B
ELOVL6 ELOVL fatty acid elongase 6
ENOSF1 enolase superfamily member 1
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GNPDA1 glucosamine-6-phosphate deaminase 1
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GYG1 glycogenin 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGA2 high mobility group AT-hook 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPB8 heat shock 22kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IPO5 importin 5
IRAK1 interleukin-1 receptor-associated kinase 1
JADE2 jade family PHD finger 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
LEPR leptin receptor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MCTP1 multiple C2 domains, transmembrane 1
MET MET proto-oncogene, receptor tyrosine kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
MRPS30 mitochondrial ribosomal protein S30
MYO5C myosin VC
NBN nibrin
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDGFA platelet-derived growth factor alpha polypeptide
PDZD8 PDZ domain containing 8
PDZK1 PDZ domain containing 1
PER2 period circadian clock 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PLK1 polo-like kinase 1
PRR7 proline rich 7 (synaptic)
PTX3 pentraxin 3, long
PUS7 pseudouridylate synthase 7 (putative)
RAD23B RAD23 homolog B (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS5 regulator of G-protein signaling 5
RPL27A ribosomal protein L27a
RPP25 ribonuclease P/MRP 25kDa subunit
RPS11 ribosomal protein S11
SENP6 SUMO1/sentrin specific peptidase 6
SEPHS1 selenophosphate synthetase 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SF3B3 splicing factor 3b, subunit 3, 130kDa
SFN stratifin
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNRPE small nuclear ribonucleoprotein polypeptide E
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBL1X transducin (beta)-like 1X-linked
TCERG1 transcription elongation regulator 1
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TMX4 thioredoxin-related transmembrane protein 4
TRAF5 TNF receptor-associated factor 5
TSC22D1 TSC22 domain family, member 1
TSPAN8 tetraspanin 8
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UPK1B uroplakin 1B
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
WSB2 WD repeat and SOCS box containing 2
XPO7 exportin 7
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB38 zinc finger and BTB domain containing 38
ZHX2 zinc fingers and homeoboxes 2