BRD-A19037878_trichostatin A_SNUC5_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-A19037878_trichostatin A_SNUC5_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ALDOC aldolase C, fructose-bisphosphate
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND3 cyclin D3
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC3B C-type lectin domain family 3, member B
CLIC3 chloride intracellular channel 3
CLU clusterin
CORO1A coronin, actin binding protein, 1A
CRABP1 cellular retinoic acid binding protein 1
CREG1 cellular repressor of E1A-stimulated genes 1
CSRP1 cysteine and glycine-rich protein 1
CTSG cathepsin G
DLK1 delta-like 1 homolog (Drosophila)
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSTN destrin (actin depolymerizing factor)
DUSP1 dual specificity phosphatase 1
EAF2 ELL associated factor 2
EDN3 endothelin 3
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EZR ezrin
FHL1 four and a half LIM domains 1
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPX3 glutathione peroxidase 3
GRN granulin
GSN gelsolin
GSTP1 glutathione S-transferase pi 1
HHEX hematopoietically expressed homeobox
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFNGR1 interferon gamma receptor 1
INSIG1 insulin induced gene 1
JAG1 jagged 1
KAZN kazrin, periplakin interacting protein
KCTD5 potassium channel tetramerization domain containing 5
LIMA1 LIM domain and actin binding 1
LSR lipolysis stimulated lipoprotein receptor
MAP7 microtubule-associated protein 7
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MBNL2 muscleblind-like splicing regulator 2
MCOLN1 mucolipin 1
MSRB1 methionine sulfoxide reductase B1
MSX1 msh homeobox 1
MT2A metallothionein 2A
NDRG1 N-myc downstream regulated 1
NOSIP nitric oxide synthase interacting protein
OSBPL8 oxysterol binding protein-like 8
PLA2G15 phospholipase A2, group XV
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLIN2 perilipin 2
PLIN3 perilipin 3
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRDX2 peroxiredoxin 2
PRSS3 protease, serine, 3
PRSS8 protease, serine, 8
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RCAN1 regulator of calcineurin 1
RIOK3 RIO kinase 3
RND1 Rho family GTPase 1
S100A14 S100 calcium binding protein A14
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STXBP1 syntaxin binding protein 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TKT transketolase
TLE4 transducin-like enhancer of split 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VAMP3 vesicle-associated membrane protein 3
VAMP7 vesicle-associated membrane protein 7
VAT1 vesicle amine transport 1
WFS1 Wolfram syndrome 1 (wolframin)
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
BNC2 basonuclin 2
CADPS2 Ca++-dependent secretion activator 2
CALB1 calbindin 1, 28kDa
CELF2 CUGBP, Elav-like family member 2
CFLAR CASP8 and FADD-like apoptosis regulator
CHL1 cell adhesion molecule L1-like
CHN1 chimerin 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMD dystrophin
EGFL6 EGF-like-domain, multiple 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMG1 EMG1 N1-specific pseudouridine methyltransferase
FAM57A family with sequence similarity 57, member A
FAM69A family with sequence similarity 69, member A
FHL2 four and a half LIM domains 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GOLGA8A golgin A8 family, member A
GSAP gamma-secretase activating protein
HMGB2 high mobility group box 2
IRS1 insulin receptor substrate 1
JADE2 jade family PHD finger 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM5D lysine (K)-specific demethylase 5D
KHNYN KH and NYN domain containing
KIAA0368 KIAA0368
KYNU kynureninase
LIPT1 lipoyltransferase 1
LPL lipoprotein lipase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPK13 mitogen-activated protein kinase 13
MECOM MDS1 and EVI1 complex locus
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUP85 nucleoporin 85kDa
OLFML2B olfactomedin-like 2B
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAD51C RAD51 paralog C
RGCC regulator of cell cycle
RPP38 ribonuclease P/MRP 38kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC35F2 solute carrier family 35, member F2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TGFBI transforming growth factor, beta-induced, 68kDa
THAP11 THAP domain containing 11
THBS1 thrombospondin 1
TMEM185B transmembrane protein 185B
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPYL5 TSPY-like 5
UPK1B uroplakin 1B
USP22 ubiquitin specific peptidase 22
ZFP36L1 ZFP36 ring finger protein-like 1