BRD-A19037878_trichostatin A_SNGM_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-A19037878_trichostatin A_SNGM_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ALDOC aldolase C, fructose-bisphosphate
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ATG2A autophagy related 2A
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C9ORF16 chromosome 9 open reading frame 16
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CERK ceramide kinase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
DGKZ diacylglycerol kinase, zeta
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFNB2 ephrin-B2
FAM117A family with sequence similarity 117, member A
FAM89B family with sequence similarity 89, member B
FGFR3 fibroblast growth factor receptor 3
FKBP1A FK506 binding protein 1A, 12kDa
FOLR1 folate receptor 1 (adult)
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GATA3 GATA binding protein 3
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRAMD4 GRAM domain containing 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPCAL1 hippocalcin-like 1
IGFBP5 insulin-like growth factor binding protein 5
KCTD5 potassium channel tetramerization domain containing 5
MAOB monoamine oxidase B
MCOLN1 mucolipin 1
MXI1 MAX interactor 1, dimerization protein
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NMU neuromedin U
NOSIP nitric oxide synthase interacting protein
NOTCH1 notch 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM4 olfactomedin 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD6 programmed cell death 6
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLA2G15 phospholipase A2, group XV
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
POR P450 (cytochrome) oxidoreductase
PRAF2 PRA1 domain family, member 2
PRSS2 protease, serine, 2 (trypsin 2)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
SCPEP1 serine carboxypeptidase 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
STX1A syntaxin 1A (brain)
TBPL1 TBP-like 1
TFF3 trefoil factor 3 (intestinal)
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TMCO1 transmembrane and coiled-coil domains 1
TRAM2 translocation associated membrane protein 2
XYLT1 xylosyltransferase I
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF331 zinc finger protein 331
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ALCAM activated leukocyte cell adhesion molecule
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA1 annexin A1
ANXA3 annexin A3
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
C2CD5 C2 calcium-dependent domain containing 5
C3ORF14 chromosome 3 open reading frame 14
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCND1 cyclin D1
CCNG1 cyclin G1
CD93 CD93 molecule
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS7 dehydrogenase/reductase (SDR family) member 7
DRAM1 DNA-damage regulated autophagy modulator 1
DST dystonin
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GBP1 guanylate binding protein 1, interferon-inducible
HMGA2 high mobility group AT-hook 2
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA10 homeobox A10
HOXB6 homeobox B6
HOXB7 homeobox B7
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IPO5 importin 5
ISG20 interferon stimulated exonuclease gene 20kDa
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LAMB3 laminin, beta 3
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMC2 laminin, gamma 2
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MMP10 matrix metallopeptidase 10
MRPL19 mitochondrial ribosomal protein L19
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMI N-myc (and STAT) interactor
NREP neuronal regeneration related protein
NUP62 nucleoporin 62kDa
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAX8 paired box 8
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLK2 polo-like kinase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRPS2 phosphoribosyl pyrophosphate synthetase 2
RAD54B RAD54 homolog B (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RDX radixin
RGS5 regulator of G-protein signaling 5
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SENP6 SUMO1/sentrin specific peptidase 6
SFN stratifin
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC43A3 solute carrier family 43, member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STEAP3 STEAP family member 3, metalloreductase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TLK1 tousled-like kinase 1
TMEM47 transmembrane protein 47
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TPM1 tropomyosin 1 (alpha)
TRIB3 tribbles pseudokinase 3
TRIM22 tripartite motif containing 22
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
WSB2 WD repeat and SOCS box containing 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon