BRD-A19037878_trichostatin A_SKMEL28_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-A19037878_trichostatin A_SKMEL28_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM9 ADAM metallopeptidase domain 9
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
ARHGAP29 Rho GTPase activating protein 29
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCL4 chemokine (C-C motif) ligand 4
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
COL8A2 collagen, type VIII, alpha 2
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CSRP1 cysteine and glycine-rich protein 1
CST6 cystatin E/M
CXCL10 chemokine (C-X-C motif) ligand 10
DES desmin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNB2 ephrin-B2
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
EXT1 exostosin glycosyltransferase 1
EZR ezrin
FBLN1 fibulin 1
FGFR1 fibroblast growth factor receptor 1
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GSDMB gasdermin B
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IL17RB interleukin 17 receptor B
IL32 interleukin 32
ISG15 ISG15 ubiquitin-like modifier
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA8 integrin, alpha 8
ITM2A integral membrane protein 2A
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS4 lectin, galactoside-binding, soluble, 4
LIMCH1 LIM and calponin homology domains 1
LYZ lysozyme
MAOA monoamine oxidase A
MAP3K7CL MAP3K7 C-terminal like
MMP7 matrix metallopeptidase 7
MN1 meningioma (disrupted in balanced translocation) 1
MX1 MX dynamin-like GTPase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYRF myelin regulatory factor
NEB nebulin
NLRP2 NLR family, pyrin domain containing 2
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PLAU plasminogen activator, urokinase
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SHB Src homology 2 domain containing adaptor protein B
SLC38A1 solute carrier family 38, member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOX9 SRY (sex determining region Y)-box 9
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM2 tropomyosin 2 (beta)
TUFT1 tuftelin 1

decreased expression

Symbol Name
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
BACE2 beta-site APP-cleaving enzyme 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CAPN3 calpain 3, (p94)
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND1 cyclin D1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHL1 cell adhesion molecule L1-like
CNPY3 canopy FGF signaling regulator 3
CXCL8 chemokine (C-X-C motif) ligand 8
DARS aspartyl-tRNA synthetase
DCLK1 doublecortin-like kinase 1
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
EDNRB endothelin receptor type B
EMP3 epithelial membrane protein 3
FCMR Fc fragment of IgM receptor
GABPB1 GA binding protein transcription factor, beta subunit 1
GOLGA8A golgin A8 family, member A
GOLT1B golgi transport 1B
GPM6B glycoprotein M6B
GRB14 growth factor receptor-bound protein 14
GSTO1 glutathione S-transferase omega 1
H1F0 H1 histone family, member 0
HAS2 hyaluronan synthase 2
HMG20B high mobility group 20B
HOXC6 homeobox C6
INTS3 integrator complex subunit 3
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
MBP myelin basic protein
MLANA melan-A
MLPH melanophilin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRN1 neuritin 1
PDLIM4 PDZ and LIM domain 4
PFKP phosphofructokinase, platelet
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PLP1 proteolipid protein 1
PMEL premelanosome protein
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PTMA prothymosin, alpha
RAD23B RAD23 homolog B (S. cerevisiae)
RCAN1 regulator of calcineurin 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
ROPN1B rhophilin associated tail protein 1B
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
S100B S100 calcium binding protein B
SELL selectin L
SFRP1 secreted frizzled-related protein 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC43A3 solute carrier family 43, member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAI2 snail family zinc finger 2
SORD sorbitol dehydrogenase
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SRSF6 serine/arginine-rich splicing factor 6
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TLK1 tousled-like kinase 1
TMED3 transmembrane emp24 protein transport domain containing 3
TNC tenascin C
TRIM2 tripartite motif containing 2
TYR tyrosinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2S ubiquitin-conjugating enzyme E2S