BRD-A19037878_trichostatin A_SKM1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

307 genes differentially expressed following the BRD-A19037878_trichostatin A_SKM1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACAA1 acetyl-CoA acyltransferase 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ADCY9 adenylate cyclase 9
AGR2 anterior gradient 2
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
AQP1 aquaporin 1 (Colton blood group)
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
ASMTL acetylserotonin O-methyltransferase-like
CADM1 cell adhesion molecule 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CES2 carboxylesterase 2
CETN2 centrin, EF-hand protein, 2
CSRP1 cysteine and glycine-rich protein 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5R1 cytochrome b5 reductase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPTOR DEP domain containing MTOR-interacting protein
DES desmin
DMPK dystrophia myotonica-protein kinase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSTN destrin (actin depolymerizing factor)
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DYNLT1 dynein, light chain, Tctex-type 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FGFR1 fibroblast growth factor receptor 1
FHL1 four and a half LIM domains 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FUCA1 fucosidase, alpha-L- 1, tissue
G0S2 G0/G1 switch 2
GCDH glutaryl-CoA dehydrogenase
GGPS1 geranylgeranyl diphosphate synthase 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNS glucosamine (N-acetyl)-6-sulfatase
GOLM1 golgi membrane protein 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
GSDMB gasdermin B
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIP1R huntingtin interacting protein 1 related
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HOOK2 hook microtubule-tethering protein 2
HOXC6 homeobox C6
HSBP1 heat shock factor binding protein 1
HSDL2 hydroxysteroid dehydrogenase like 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
IQCK IQ motif containing K
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JAK1 Janus kinase 1
JUN jun proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM3A lysine (K)-specific demethylase 3A
LDB3 LIM domain binding 3
LIMA1 LIM domain and actin binding 1
MALL mal, T-cell differentiation protein-like
MAPT microtubule-associated protein tau
MB myoglobin
MCOLN1 mucolipin 1
MEG3 maternally expressed 3 (non-protein coding)
MLF1 myeloid leukemia factor 1
MPZL1 myelin protein zero-like 1
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MVP major vault protein
MYO1D myosin ID
NCOA3 nuclear receptor coactivator 3
NEB nebulin
NEU1 sialidase 1 (lysosomal sialidase)
NFIB nuclear factor I/B
NINL ninein-like
NOSIP nitric oxide synthase interacting protein
NPTX2 neuronal pentraxin II
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAT ornithine aminotransferase
OSTM1 osteopetrosis associated transmembrane protein 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PEPD peptidase D
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLA2G15 phospholipase A2, group XV
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRSS3 protease, serine, 3
PSAP prosaposin
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB29 RAB29, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBKS ribokinase
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRAGC Ras-related GTP binding C
RWDD1 RWD domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC46A3 solute carrier family 46, member 3
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMYD3 SET and MYND domain containing 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRPX sushi-repeat containing protein, X-linked
STX7 syntaxin 7
SYNM synemin, intermediate filament protein
TKTL1 transketolase-like 1
TMEM41B transmembrane protein 41B
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TSPAN1 tetraspanin 1
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUFT1 tuftelin 1
VAMP3 vesicle-associated membrane protein 3
VAT1 vesicle amine transport 1
YPEL5 yippee-like 5 (Drosophila)
ZNF211 zinc finger protein 211
ZNF331 zinc finger protein 331
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADCY7 adenylate cyclase 7
ADGRE5 adhesion G protein-coupled receptor E5
ADNP activity-dependent neuroprotector homeobox
ALCAM activated leukocyte cell adhesion molecule
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGAP15 Rho GTPase activating protein 15
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATP8B4 ATPase, class I, type 8B, member 4
AZU1 azurocidin 1
BAG2 BCL2-associated athanogene 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
CCNA2 cyclin A2
CD302 CD302 molecule
CD58 CD58 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CELF2 CUGBP, Elav-like family member 2
CES1 carboxylesterase 1
CHD7 chromodomain helicase DNA binding protein 7
CLIC1 chloride intracellular channel 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COMT catechol-O-methyltransferase
CSK c-src tyrosine kinase
CST7 cystatin F (leukocystatin)
CTSC cathepsin C
CTSG cathepsin G
CYB5R2 cytochrome b5 reductase 2
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUOX2 dual oxidase 2
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
ELF1 E74-like factor 1 (ets domain transcription factor)
EMP3 epithelial membrane protein 3
EVI2A ecotropic viral integration site 2A
EVI2B ecotropic viral integration site 2B
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FAR2 fatty acyl CoA reductase 2
FBXO7 F-box protein 7
FGA fibrinogen alpha chain
FHL2 four and a half LIM domains 2
FXYD5 FXYD domain containing ion transport regulator 5
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GSTO1 glutathione S-transferase omega 1
HDGF hepatoma-derived growth factor
HDGFRP3 hepatoma-derived growth factor, related protein 3
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HOXA10 homeobox A10
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INPP1 inositol polyphosphate-1-phosphatase
IRAK1 interleukin-1 receptor-associated kinase 1
IRS2 insulin receptor substrate 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KEAP1 kelch-like ECH-associated protein 1
LARP4B La ribonucleoprotein domain family, member 4B
LAT2 linker for activation of T cells family, member 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
MBP myelin basic protein
MCTP1 multiple C2 domains, transmembrane 1
MGST2 microsomal glutathione S-transferase 2
MNDA myeloid cell nuclear differentiation antigen
MYC v-myc avian myelocytomatosis viral oncogene homolog
NMI N-myc (and STAT) interactor
NOP16 NOP16 nucleolar protein
NREP neuronal regeneration related protein
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
ORM1 orosomucoid 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PLEK pleckstrin
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PON2 paraoxonase 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRTN3 proteinase 3
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SEH1L SEH1-like (S. cerevisiae)
SENP6 SUMO1/sentrin specific peptidase 6
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC43A3 solute carrier family 43, member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC1A structural maintenance of chromosomes 1A
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STS steroid sulfatase (microsomal), isozyme S
TCERG1 transcription elongation regulator 1
TEX10 testis expressed 10
TF transferrin
TKT transketolase
TLK1 tousled-like kinase 1
TLR4 toll-like receptor 4
TNS3 tensin 3
TXN thioredoxin
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WIPF1 WAS/WASL interacting protein family, member 1
WSB2 WD repeat and SOCS box containing 2
XPOT exportin, tRNA
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZEB2 zinc finger E-box binding homeobox 2
ZMIZ1 zinc finger, MIZ-type containing 1