BRD-A19037878_trichostatin A_SKLU1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-A19037878_trichostatin A_SKLU1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ABLIM1 actin binding LIM protein 1
ACOT7 acyl-CoA thioesterase 7
ADA adenosine deaminase
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOB aldolase B, fructose-bisphosphate
ASMTL acetylserotonin O-methyltransferase-like
ATP10D ATPase, class V, type 10D
BICD2 bicaudal D homolog 2 (Drosophila)
BLNK B-cell linker
BPHL biphenyl hydrolase-like (serine hydrolase)
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CORO1A coronin, actin binding protein, 1A
CPA3 carboxypeptidase A3 (mast cell)
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CYB5A cytochrome b5 type A (microsomal)
CYB5R1 cytochrome b5 reductase 1
CYTH1 cytohesin 1
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELN elastin
EPAS1 endothelial PAS domain protein 1
F11R F11 receptor
FBLN5 fibulin 5
FKBP1B FK506 binding protein 1B, 12.6 kDa
FRY furry homolog (Drosophila)
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GRK5 G protein-coupled receptor kinase 5
GSTA4 glutathione S-transferase alpha 4
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HEBP1 heme binding protein 1
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOOK2 hook microtubule-tethering protein 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HRSP12 heat-responsive protein 12
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA2 heat shock 70kDa protein 2
HSPB8 heat shock 22kDa protein 8
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL32 interleukin 32
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
KCTD5 potassium channel tetramerization domain containing 5
LCK LCK proto-oncogene, Src family tyrosine kinase
LIPA lipase A, lysosomal acid, cholesterol esterase
LOC100272216 uncharacterized LOC100272216
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MGST3 microsomal glutathione S-transferase 3
MN1 meningioma (disrupted in balanced translocation) 1
MTSS1 metastasis suppressor 1
MXRA7 matrix-remodelling associated 7
MYO1B myosin IB
NPC1 Niemann-Pick disease, type C1
NQO2 NAD(P)H dehydrogenase, quinone 2
OSBPL8 oxysterol binding protein-like 8
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLB polymerase (DNA directed), beta
PROM1 prominin 1
PTPRE protein tyrosine phosphatase, receptor type, E
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RBM47 RNA binding motif protein 47
RCAN1 regulator of calcineurin 1
REG1A regenerating islet-derived 1 alpha
REG1B regenerating islet-derived 1 beta
RGS16 regulator of G-protein signaling 16
RHCG Rh family, C glycoprotein
RHOB ras homolog family member B
ROGDI rogdi homolog (Drosophila)
RUFY2 RUN and FYVE domain containing 2
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNN stannin
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STX12 syntaxin 12
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFA transforming growth factor, alpha
TIMP3 TIMP metallopeptidase inhibitor 3
TLE4 transducin-like enhancer of split 4
TPD52 tumor protein D52
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
VAT1 vesicle amine transport 1
VCAN versican
VNN1 vanin 1
ZNF331 zinc finger protein 331
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACSL5 acyl-CoA synthetase long-chain family member 5
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ATF1 activating transcription factor 1
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
C6ORF62 chromosome 6 open reading frame 62
CADPS2 Ca++-dependent secretion activator 2
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CHN2 chimerin 2
CPVL carboxypeptidase, vitellogenic-like
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF4B eukaryotic translation initiation factor 4B
ELF4 E74-like factor 4 (ets domain transcription factor)
EMP3 epithelial membrane protein 3
FAM57A family with sequence similarity 57, member A
FKBP10 FK506 binding protein 10, 65 kDa
FOSL1 FOS-like antigen 1
GSAP gamma-secretase activating protein
GSTO1 glutathione S-transferase omega 1
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDO1 indoleamine 2,3-dioxygenase 1
IFRD2 interferon-related developmental regulator 2
IL6ST interleukin 6 signal transducer
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
MARCKS myristoylated alanine-rich protein kinase C substrate
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
MOXD1 monooxygenase, DBH-like 1
MSLN mesothelin
NMI N-myc (and STAT) interactor
NUDCD3 NudC domain containing 3
NUP62 nucleoporin 62kDa
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAX8 paired box 8
PDGFC platelet derived growth factor C
PDLIM4 PDZ and LIM domain 4
PLAUR plasminogen activator, urokinase receptor
PLTP phospholipid transfer protein
PRR7 proline rich 7 (synaptic)
PTPRC protein tyrosine phosphatase, receptor type, C
PTX3 pentraxin 3, long
RAD23B RAD23 homolog B (S. cerevisiae)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SPRY2 sprouty homolog 2 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
USP1 ubiquitin specific peptidase 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
ZBTB38 zinc finger and BTB domain containing 38