BRD-A19037878_trichostatin A_RMUGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

180 genes differentially expressed following the BRD-A19037878_trichostatin A_RMUGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
APLP2 amyloid beta (A4) precursor-like protein 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAMBI BMP and activin membrane-bound inhibitor
BLVRA biliverdin reductase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
C4BPA complement component 4 binding protein, alpha
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND2 cyclin D2
CCND3 cyclin D3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CPB1 carboxypeptidase B1 (tissue)
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP1 cysteine and glycine-rich protein 1
DDIT4 DNA-damage-inducible transcript 4
DMBT1 deleted in malignant brain tumors 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EDNRA endothelin receptor type A
EFNB2 ephrin-B2
EIF5A eukaryotic translation initiation factor 5A
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FBLN5 fibulin 5
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GSN gelsolin
HIST1H1C histone cluster 1, H1c
HIST1H3H histone cluster 1, H3h
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HPCAL1 hippocalcin-like 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
KIAA0513 KIAA0513
KIF5C kinesin family member 5C
KLF4 Kruppel-like factor 4 (gut)
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LOXL2 lysyl oxidase-like 2
LPIN1 lipin 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MCOLN1 mucolipin 1
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
NUTF2 nuclear transport factor 2
OAT ornithine aminotransferase
OLFM1 olfactomedin 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCDH9 protocadherin 9
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G15 phospholipase A2, group XV
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PNMA2 paraneoplastic Ma antigen 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCZ protein kinase C, zeta
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
REG1A regenerating islet-derived 1 alpha
RRAGD Ras-related GTP binding D
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THY1 Thy-1 cell surface antigen
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TPD52 tumor protein D52
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
WDR47 WD repeat domain 47
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
COMT catechol-O-methyltransferase
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EMX2 empty spiracles homeobox 2
FAM60A family with sequence similarity 60, member A
GOSR1 golgi SNAP receptor complex member 1
GTPBP8 GTP-binding protein 8 (putative)
HMGA2 high mobility group AT-hook 2
HOXB7 homeobox B7
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
LOC100505650 uncharacterized LOC100505650
LPL lipoprotein lipase
LTF lactotransferrin
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MUC16 mucin 16, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NTS neurotensin
PARP2 poly (ADP-ribose) polymerase 2
PAX8 paired box 8
PFN2 profilin 2
PGLS 6-phosphogluconolactonase
PLK1 polo-like kinase 1
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PUF60 poly-U binding splicing factor 60KDa
RPL38 ribosomal protein L38
S100A2 S100 calcium binding protein A2
SENP6 SUMO1/sentrin specific peptidase 6
SFRP1 secreted frizzled-related protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TNS3 tensin 3
TPD52L1 tumor protein D52-like 1
UPK1B uroplakin 1B
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZHX2 zinc fingers and homeoboxes 2
ZNF91 zinc finger protein 91
ZW10 zw10 kinetochore protein