BRD-A19037878_trichostatin A_RMGI_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-A19037878_trichostatin A_RMGI_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
ABHD6 abhydrolase domain containing 6
ABLIM1 actin binding LIM protein 1
ACOT7 acyl-CoA thioesterase 7
ADCY9 adenylate cyclase 9
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANO10 anoctamin 10
ANPEP alanyl (membrane) aminopeptidase
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF3 activating transcription factor 3
BASP1 brain abundant, membrane attached signal protein 1
BTG2 BTG family, member 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPG capping protein (actin filament), gelsolin-like
CAST calpastatin
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CECR1 cat eye syndrome chromosome region, candidate 1
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC4 chloride intracellular channel 4
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
COLEC11 collectin sub-family member 11
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DSTN destrin (actin depolymerizing factor)
DUSP10 dual specificity phosphatase 10
EFHD1 EF-hand domain family, member D1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERLIN2 ER lipid raft associated 2
FAM134B family with sequence similarity 134, member B
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GREM1 gremlin 1, DAN family BMP antagonist
HAMP hepcidin antimicrobial peptide
HIST3H2A histone cluster 3, H2a
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPCAL1 hippocalcin-like 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
LGALS1 lectin, galactoside-binding, soluble, 1
LGMN legumain
LIMA1 LIM domain and actin binding 1
MAP7 microtubule-associated protein 7
MEIS1 Meis homeobox 1
MGP matrix Gla protein
MGST3 microsomal glutathione S-transferase 3
MSRA methionine sulfoxide reductase A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NQO2 NAD(P)H dehydrogenase, quinone 2
PEG3 paternally expressed 3
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLA2G15 phospholipase A2, group XV
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RTN3 reticulon 3
SATB1 SATB homeobox 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMYD3 SET and MYND domain containing 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SST somatostatin
STK38L serine/threonine kinase 38 like
TAGLN transgelin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNS1 tensin 1
TOB1 transducer of ERBB2, 1
TRAK2 trafficking protein, kinesin binding 2
TRAM2 translocation associated membrane protein 2
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
UBA7 ubiquitin-like modifier activating enzyme 7
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VAT1 vesicle amine transport 1
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ATF5 activating transcription factor 5
C6ORF62 chromosome 6 open reading frame 62
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCND1 cyclin D1
CDC42 cell division cycle 42
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DST dystonin
EREG epiregulin
FAM57A family with sequence similarity 57, member A
FBXO11 F-box protein 11
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
HMGB2 high mobility group box 2
IGF1 insulin-like growth factor 1 (somatomedin C)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0368 KIAA0368
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP1B microtubule-associated protein 1B
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MICALL1 MICAL-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NKX3-1 NK3 homeobox 1
NUP62 nucleoporin 62kDa
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTGES prostaglandin E synthase
PTHLH parathyroid hormone-like hormone
PUF60 poly-U binding splicing factor 60KDa
RBM26 RNA binding motif protein 26
RBM47 RNA binding motif protein 47
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SEPT9 septin 9
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX17 SRY (sex determining region Y)-box 17
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLR4 toll-like receptor 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
UBE2C ubiquitin-conjugating enzyme E2C
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP1 ubiquitin specific peptidase 1
WTAP Wilms tumor 1 associated protein