BRD-A19037878_trichostatin A_RKO_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

213 genes differentially expressed following the BRD-A19037878_trichostatin A_RKO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACOT7 acyl-CoA thioesterase 7
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
ALB albumin
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ARHGAP29 Rho GTPase activating protein 29
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BLNK B-cell linker
BTG2 BTG family, member 2
C1QB complement component 1, q subcomponent, B chain
C3 complement component 3
C3ORF14 chromosome 3 open reading frame 14
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL4 chemokine (C-C motif) ligand 4
CCND3 cyclin D3
CD22 CD22 molecule
CD24 CD24 molecule
CDC20 cell division cycle 20
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CPE carboxypeptidase E
CSRP1 cysteine and glycine-rich protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCXR dicarbonyl/L-xylulose reductase
DEFA4 defensin, alpha 4, corticostatin
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EAF2 ELL associated factor 2
EFNB2 ephrin-B2
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FADS3 fatty acid desaturase 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPX3 glutathione peroxidase 3
GUK1 guanylate kinase 1
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
IFT57 intraflagellar transport 57
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL6ST interleukin 6 signal transducer
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
KRT7 keratin 7, type II
L1CAM L1 cell adhesion molecule
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPT microtubule-associated protein tau
MGLL monoglyceride lipase
MICB MHC class I polypeptide-related sequence B
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MVP major vault protein
NOSIP nitric oxide synthase interacting protein
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
OSTM1 osteopetrosis associated transmembrane protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
POLB polymerase (DNA directed), beta
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PXMP2 peroxisomal membrane protein 2, 22kDa
QPCT glutaminyl-peptide cyclotransferase
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RNF167 ring finger protein 167
SDC3 syndecan 3
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SLC46A3 solute carrier family 46, member 3
SRGN serglycin
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
TM7SF2 transmembrane 7 superfamily member 2
TNS1 tensin 1
TUBA4A tubulin, alpha 4a
WDR47 WD repeat domain 47
XIST X inactive specific transcript (non-protein coding)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ANXA5 annexin A5
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOLD1 apolipoprotein L domain containing 1
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
BTG3 BTG family, member 3
CAPN2 calpain 2, (m/II) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB2 cyclin B2
CD93 CD93 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CST3 cystatin C
CSTA cystatin A (stefin A)
CYFIP1 cytoplasmic FMR1 interacting protein 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DICER1 dicer 1, ribonuclease type III
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM57A family with sequence similarity 57, member A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FHL2 four and a half LIM domains 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLUL glutamate-ammonia ligase
GSAP gamma-secretase activating protein
GSTO1 glutathione S-transferase omega 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM2 interferon induced transmembrane protein 2
IGFBP6 insulin-like growth factor binding protein 6
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KLF4 Kruppel-like factor 4 (gut)
KRIT1 KRIT1, ankyrin repeat containing
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MGST2 microsomal glutathione S-transferase 2
MICALL1 MICAL-like 1
MMP9 matrix metallopeptidase 9
MX2 MX dynamin-like GTPase 2
MYBPC1 myosin binding protein C, slow type
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PI3 peptidase inhibitor 3, skin-derived
PLSCR3 phospholipid scramblase 3
PODXL podocalyxin-like
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
SDC2 syndecan 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SETBP1 SET binding protein 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1A small proline-rich protein 1A
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TLK2 tousled-like kinase 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNC1 troponin C type 1 (slow)
TRIM14 tripartite motif containing 14
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
USP22 ubiquitin specific peptidase 22
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
XAF1 XIAP associated factor 1
YBX3 Y box binding protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon