BRD-A19037878_trichostatin A_PL21_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

241 genes differentially expressed following the BRD-A19037878_trichostatin A_PL21_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACOT7 acyl-CoA thioesterase 7
ACSL3 acyl-CoA synthetase long-chain family member 3
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
ARL3 ADP-ribosylation factor-like 3
ASMTL acetylserotonin O-methyltransferase-like
ATG2A autophagy related 2A
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPHL biphenyl hydrolase-like (serine hydrolase)
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CPNE3 copine III
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5R1 cytochrome b5 reductase 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DYNLT1 dynein, light chain, Tctex-type 1
ETV5 ets variant 5
EZR ezrin
FABP7 fatty acid binding protein 7, brain
FBLN5 fibulin 5
FGFR3 fibroblast growth factor receptor 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GALE UDP-galactose-4-epimerase
GAS6 growth arrest-specific 6
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GOLGB1 golgin B1
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOOK2 hook microtubule-tethering protein 2
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
IRF7 interferon regulatory factor 7
KCTD5 potassium channel tetramerization domain containing 5
KIFAP3 kinesin-associated protein 3
KLK11 kallikrein-related peptidase 11
MALL mal, T-cell differentiation protein-like
MAPT microtubule-associated protein tau
MCOLN1 mucolipin 1
MGLL monoglyceride lipase
MMP12 matrix metallopeptidase 12
MPZL1 myelin protein zero-like 1
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
NEB nebulin
NEU1 sialidase 1 (lysosomal sialidase)
NLRP2 NLR family, pyrin domain containing 2
NOSIP nitric oxide synthase interacting protein
NPTX2 neuronal pentraxin II
NQO2 NAD(P)H dehydrogenase, quinone 2
NRCAM neuronal cell adhesion molecule
OAT ornithine aminotransferase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEG10 paternally expressed 10
PFKM phosphofructokinase, muscle
PLA2G15 phospholipase A2, group XV
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLB polymerase (DNA directed), beta
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRAF2 PRA1 domain family, member 2
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS3 protease, serine, 3
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RGS2 regulator of G-protein signaling 2
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC46A3 solute carrier family 46, member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SMYD3 SET and MYND domain containing 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRPX sushi-repeat containing protein, X-linked
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM41B transmembrane protein 41B
TOB1 transducer of ERBB2, 1
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
VAMP3 vesicle-associated membrane protein 3

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTN1 actinin, alpha 1
ADI1 acireductone dioxygenase 1
AHSG alpha-2-HS-glycoprotein
AKAP8 A kinase (PRKA) anchor protein 8
ALB albumin
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
APOA2 apolipoprotein A-II
APOB apolipoprotein B
ARHGAP15 Rho GTPase activating protein 15
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
AZU1 azurocidin 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
CCL2 chemokine (C-C motif) ligand 2
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES1 carboxylesterase 1
CLEC11A C-type lectin domain family 11, member A
COCH cochlin
COMT catechol-O-methyltransferase
CSK c-src tyrosine kinase
CST7 cystatin F (leukocystatin)
CTPS1 CTP synthase 1
CTSC cathepsin C
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
DIAPH2 diaphanous-related formin 2
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
ELF1 E74-like factor 1 (ets domain transcription factor)
ELOVL6 ELOVL fatty acid elongase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EVI2B ecotropic viral integration site 2B
FAM60A family with sequence similarity 60, member A
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLIPR1 GLI pathogenesis-related 1
GSAP gamma-secretase activating protein
GUSBP3 glucuronidase, beta pseudogene 3
HMGB2 high mobility group box 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IARS isoleucyl-tRNA synthetase
IGFBP7 insulin-like growth factor binding protein 7
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMS1 LIM and senescent cell antigen-like domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LYZ lysozyme
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
METTL7A methyltransferase like 7A
MFSD1 major facilitator superfamily domain containing 1
MGST2 microsomal glutathione S-transferase 2
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MRPS30 mitochondrial ribosomal protein S30
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDGFC platelet derived growth factor C
PHACTR2 phosphatase and actin regulator 2
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLAC8 placenta-specific 8
PLEK pleckstrin
PLK1 polo-like kinase 1
PTN pleiotrophin
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RBMX RNA binding motif protein, X-linked
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPL31 ribosomal protein L31
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYK spleen tyrosine kinase
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TEX10 testis expressed 10
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TYMS thymidylate synthetase
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YBX3 Y box binding protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2