BRD-A19037878_trichostatin A_OV7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

182 genes differentially expressed following the BRD-A19037878_trichostatin A_OV7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADD3 adducin 3 (gamma)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
CALD1 caldesmon 1
CCDC92 coiled-coil domain containing 92
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CKB creatine kinase, brain
CLIC4 chloride intracellular channel 4
CNPY3 canopy FGF signaling regulator 3
COBL cordon-bleu WH2 repeat protein
CPE carboxypeptidase E
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
FAM134B family with sequence similarity 134, member B
FBXL12 F-box and leucine-rich repeat protein 12
FOLR1 folate receptor 1 (adult)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLO1 glyoxalase I
GLRX glutaredoxin (thioltransferase)
GPC3 glypican 3
GRB10 growth factor receptor-bound protein 10
HBB hemoglobin, beta
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IFNGR1 interferon gamma receptor 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCTD5 potassium channel tetramerization domain containing 5
MAGEA3 melanoma antigen family A3
MAP7 microtubule-associated protein 7
NDRG1 N-myc downstream regulated 1
NOSIP nitric oxide synthase interacting protein
PCP4 Purkinje cell protein 4
PDLIM1 PDZ and LIM domain 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PPAP2A phosphatidic acid phosphatase type 2A
PRKCB protein kinase C, beta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
S100P S100 calcium binding protein P
SGPP1 sphingosine-1-phosphate phosphatase 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIRT3 sirtuin 3
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SPON2 spondin 2, extracellular matrix protein
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TIMP3 TIMP metallopeptidase inhibitor 3
TPSAB1 tryptase alpha/beta 1
TSPAN13 tetraspanin 13
TUBB2B tubulin, beta 2B class IIb
WDR61 WD repeat domain 61

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
APOD apolipoprotein D
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
C1R complement component 1, r subcomponent
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNB2 cyclin B2
CCND1 cyclin D1
CD163 CD163 molecule
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK4 cyclin-dependent kinase 4
CFI complement factor I
CHMP4A charged multivesicular body protein 4A
COL1A2 collagen, type I, alpha 2
CRISP3 cysteine-rich secretory protein 3
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP4 dual specificity phosphatase 4
E2F2 E2F transcription factor 2
EGFR epidermal growth factor receptor
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPS8 epidermal growth factor receptor pathway substrate 8
ETV1 ets variant 1
FBN1 fibrillin 1
FHL2 four and a half LIM domains 2
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GANAB glucosidase, alpha; neutral AB
GDF15 growth differentiation factor 15
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSPT2 G1 to S phase transition 2
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXB6 homeobox B6
HOXB7 homeobox B7
IGFBP6 insulin-like growth factor binding protein 6
IRAK1 interleukin-1 receptor-associated kinase 1
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KHNYN KH and NYN domain containing
KIAA0368 KIAA0368
KPNB1 karyopherin (importin) beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LIMS1 LIM and senescent cell antigen-like domains 1
LOX lysyl oxidase
LXN latexin
LY96 lymphocyte antigen 96
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL1 muscleblind-like splicing regulator 1
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MRPS16 mitochondrial ribosomal protein S16
MRPS30 mitochondrial ribosomal protein S30
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFE2L1 nuclear factor, erythroid 2-like 1
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PDGFC platelet derived growth factor C
PDZD8 PDZ domain containing 8
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POU2AF1 POU class 2 associating factor 1
PPIF peptidylprolyl isomerase F
PSD3 pleckstrin and Sec7 domain containing 3
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
RAD23B RAD23 homolog B (S. cerevisiae)
RGS4 regulator of G-protein signaling 4
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEC62 SEC62 homolog (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TNS3 tensin 3
TP53 tumor protein p53
TPD52L1 tumor protein D52-like 1
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP22 ubiquitin specific peptidase 22
VCAN versican
VEGFC vascular endothelial growth factor C
XBP1 X-box binding protein 1
ZBTB38 zinc finger and BTB domain containing 38
ZIC1 Zic family member 1
ZNF22 zinc finger protein 22