BRD-A19037878_trichostatin A_NCIH596_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

208 genes differentially expressed following the BRD-A19037878_trichostatin A_NCIH596_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALB albumin
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
BIK BCL2-interacting killer (apoptosis-inducing)
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTK Bruton agammaglobulinemia tyrosine kinase
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNG2 cyclin G2
CD22 CD22 molecule
CD24 CD24 molecule
CD52 CD52 molecule
CD72 CD72 molecule
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CORO1A coronin, actin binding protein, 1A
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5R1 cytochrome b5 reductase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFHD1 EF-hand domain family, member D1
EZR ezrin
FABP1 fatty acid binding protein 1, liver
FAM69A family with sequence similarity 69, member A
FOXO4 forkhead box O4
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GRN granulin
GUSBP11 glucuronidase, beta pseudogene 11
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSBP1 heat shock factor binding protein 1
HSPA2 heat shock 70kDa protein 2
HTRA1 HtrA serine peptidase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
ISG15 ISG15 ubiquitin-like modifier
KCTD5 potassium channel tetramerization domain containing 5
KIAA0226L KIAA0226-like
KIAA0355 KIAA0355
LGALS4 lectin, galactoside-binding, soluble, 4
LIMA1 LIM domain and actin binding 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MUC2 mucin 2, oligomeric mucus/gel-forming
NEU1 sialidase 1 (lysosomal sialidase)
NOSIP nitric oxide synthase interacting protein
NR2F6 nuclear receptor subfamily 2, group F, member 6
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLA2G15 phospholipase A2, group XV
PNMA2 paraneoplastic Ma antigen 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RAP2A RAP2A, member of RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFTN1 raftlin, lipid raft linker 1
RHOB ras homolog family member B
RIMS3 regulating synaptic membrane exocytosis 3
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
STK38 serine/threonine kinase 38
STX7 syntaxin 7
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TCL1A T-cell leukemia/lymphoma 1A
TFF3 trefoil factor 3 (intestinal)
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM176B transmembrane protein 176B
TRIL TLR4 interactor with leucine-rich repeats
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADCY3 adenylate cyclase 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BHLHE41 basic helix-loop-helix family, member e41
C6ORF62 chromosome 6 open reading frame 62
CBR3 carbonyl reductase 3
CNIH1 cornichon family AMPA receptor auxiliary protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCTD dCMP deaminase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
F12 coagulation factor XII (Hageman factor)
FAM57A family with sequence similarity 57, member A
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPX2 glutathione peroxidase 2
HACD1 3-hydroxyacyl-CoA dehydratase 1
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KLF4 Kruppel-like factor 4 (gut)
KLK2 kallikrein-related peptidase 2
KRT13 keratin 13, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LAMC1 laminin, gamma 1 (formerly LAMB2)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MET MET proto-oncogene, receptor tyrosine kinase
MGST2 microsomal glutathione S-transferase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPS30 mitochondrial ribosomal protein S30
MSMB microseminoprotein, beta-
MTA1 metastasis associated 1
MYH11 myosin, heavy chain 11, smooth muscle
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NKX3-1 NK3 homeobox 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PARVB parvin, beta
PFN2 profilin 2
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PRMT1 protein arginine methyltransferase 1
PRNP prion protein
PRR7 proline rich 7 (synaptic)
PSCA prostate stem cell antigen
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL36AL ribosomal protein L36a-like
RPP25 ribonuclease P/MRP 25kDa subunit
S100A2 S100 calcium binding protein A2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC35F2 solute carrier family 35, member F2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS2 sorbin and SH3 domain containing 2
SORD sorbitol dehydrogenase
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIM16 tripartite motif containing 16
TRIP6 thyroid hormone receptor interactor 6
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TXN thioredoxin
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE3C ubiquitin protein ligase E3C
USP22 ubiquitin specific peptidase 22
VANGL1 VANGL planar cell polarity protein 1
WSB2 WD repeat and SOCS box containing 2
YBX3 Y box binding protein 3
ZIC1 Zic family member 1