BRD-A19037878_trichostatin A_NCIH2073_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-A19037878_trichostatin A_NCIH2073_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ADCY9 adenylate cyclase 9
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ARL3 ADP-ribosylation factor-like 3
ASMTL acetylserotonin O-methyltransferase-like
BIK BCL2-interacting killer (apoptosis-inducing)
BZW2 basic leucine zipper and W2 domains 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
CYB5A cytochrome b5 type A (microsomal)
CYB5R1 cytochrome b5 reductase 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DHCR24 24-dehydrocholesterol reductase
DUSP14 dual specificity phosphatase 14
EFNB2 ephrin-B2
FAR2 fatty acyl CoA reductase 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GSDMB gasdermin B
HAL histidine ammonia-lyase
HAMP hepcidin antimicrobial peptide
HEBP1 heme binding protein 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INHBA inhibin, beta A
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCTD5 potassium channel tetramerization domain containing 5
KIAA0226L KIAA0226-like
KLK5 kallikrein-related peptidase 5
LGMN legumain
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLF1 myeloid leukemia factor 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYB v-myb avian myeloblastosis viral oncogene homolog
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
PLA2G15 phospholipase A2, group XV
PRSS2 protease, serine, 2 (trypsin 2)
PTPRE protein tyrosine phosphatase, receptor type, E
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RIMS3 regulating synaptic membrane exocytosis 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTN3 reticulon 3
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC46A3 solute carrier family 46, member 3
SMYD3 SET and MYND domain containing 3
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STXBP1 syntaxin binding protein 1
TBX2 T-box 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TGFA transforming growth factor, alpha
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPST2 tyrosylprotein sulfotransferase 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
UST uronyl-2-sulfotransferase
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
C6ORF62 chromosome 6 open reading frame 62
CCL2 chemokine (C-C motif) ligand 2
COL5A1 collagen, type V, alpha 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DPT dermatopontin
DPYD dihydropyrimidine dehydrogenase
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4B eukaryotic translation initiation factor 4B
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GBP1 guanylate binding protein 1, interferon-inducible
GNAS GNAS complex locus
GPR171 G protein-coupled receptor 171
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXB2 homeobox B2
HOXB7 homeobox B7
IFI16 interferon, gamma-inducible protein 16
IL7R interleukin 7 receptor
KEAP1 kelch-like ECH-associated protein 1
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KYNU kynureninase
LAMB1 laminin, beta 1
LCN2 lipocalin 2
LPAR1 lysophosphatidic acid receptor 1
LTF lactotransferrin
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
MET MET proto-oncogene, receptor tyrosine kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMB microseminoprotein, beta-
NFIB nuclear factor I/B
NID1 nidogen 1
NRIP1 nuclear receptor interacting protein 1
PAPOLA poly(A) polymerase alpha
PARP2 poly (ADP-ribose) polymerase 2
PDAP1 PDGFA associated protein 1
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PSCA prostate stem cell antigen
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
PTX3 pentraxin 3, long
RAD23B RAD23 homolog B (S. cerevisiae)
RNF167 ring finger protein 167
RREB1 ras responsive element binding protein 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB2A1 secretoglobin, family 2A, member 1
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SFRP1 secreted frizzled-related protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SPG20 spastic paraplegia 20 (Troyer syndrome)
SRGN serglycin
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TMPO thymopoietin
TRIP6 thyroid hormone receptor interactor 6
TSKU tsukushi, small leucine rich proteoglycan
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UPK1B uroplakin 1B
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
WIPF1 WAS/WASL interacting protein family, member 1
WWTR1 WW domain containing transcription regulator 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB38 zinc finger and BTB domain containing 38
ZFP36L1 ZFP36 ring finger protein-like 1