BRD-A19037878_trichostatin A_LOVO_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

208 genes differentially expressed following the BRD-A19037878_trichostatin A_LOVO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACOT7 acyl-CoA thioesterase 7
ACSL3 acyl-CoA synthetase long-chain family member 3
ADD3 adducin 3 (gamma)
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ARHGAP29 Rho GTPase activating protein 29
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAD BCL2-associated agonist of cell death
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND3 cyclin D3
CETN2 centrin, EF-hand protein, 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP1B charged multivesicular body protein 1B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCA1 chloride channel accessory 1
CLDN10 claudin 10
CORO1A coronin, actin binding protein, 1A
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CRIP2 cysteine-rich protein 2
CYB5R1 cytochrome b5 reductase 1
CYLD cylindromatosis (turban tumor syndrome)
DHCR7 7-dehydrocholesterol reductase
DSTN destrin (actin depolymerizing factor)
EAF2 ELL associated factor 2
EIF5A eukaryotic translation initiation factor 5A
ETHE1 ethylmalonic encephalopathy 1
EZR ezrin
FAM117A family with sequence similarity 117, member A
FBXO11 F-box protein 11
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLA galactosidase, alpha
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLGA7 golgin A7
HEBP1 heme binding protein 1
HIST1H3H histone cluster 1, H3h
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
IQCG IQ motif containing G
JAG1 jagged 1
JUN jun proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF10 Kruppel-like factor 10
LPXN leupaxin
MAGED1 melanoma antigen family D1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MCOLN1 mucolipin 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MGST3 microsomal glutathione S-transferase 3
MLF1 myeloid leukemia factor 1
MMD monocyte to macrophage differentiation-associated
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NCALD neurocalcin delta
NLRP2 NLR family, pyrin domain containing 2
NOSIP nitric oxide synthase interacting protein
NQO1 NAD(P)H dehydrogenase, quinone 1
PALLD palladin, cytoskeletal associated protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLA2G15 phospholipase A2, group XV
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RGS2 regulator of G-protein signaling 2
RRBP1 ribosome binding protein 1
RTN3 reticulon 3
SEPP1 selenoprotein P, plasma, 1
SF3B5 splicing factor 3b, subunit 5, 10kDa
SGK1 serum/glucocorticoid regulated kinase 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNX11 sorting nexin 11
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQRDL sulfide quinone reductase-like (yeast)
SST somatostatin
STAB1 stabilin 1
STX7 syntaxin 7
STXBP1 syntaxin binding protein 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM50B transmembrane protein 50B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAK2 trafficking protein, kinesin binding 2
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADORA2B adenosine A2b receptor
AGTR1 angiotensin II receptor, type 1
AKAP8 A kinase (PRKA) anchor protein 8
ALCAM activated leukocyte cell adhesion molecule
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
APOD apolipoprotein D
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BMP4 bone morphogenetic protein 4
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CADPS2 Ca++-dependent secretion activator 2
CALB1 calbindin 1, 28kDa
CCNA2 cyclin A2
CCND1 cyclin D1
CDC20 cell division cycle 20
CNPY3 canopy FGF signaling regulator 3
COMT catechol-O-methyltransferase
CTPS1 CTP synthase 1
CXCL11 chemokine (C-X-C motif) ligand 11
DACH1 dachshund family transcription factor 1
DCTD dCMP deaminase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
ELOVL1 ELOVL fatty acid elongase 1
ESR1 estrogen receptor 1
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
GRIA2 glutamate receptor, ionotropic, AMPA 2
HDDC2 HD domain containing 2
HMGB2 high mobility group box 2
HNMT histamine N-methyltransferase
HOXC6 homeobox C6
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IL1RN interleukin 1 receptor antagonist
IPO5 importin 5
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KIAA0368 KIAA0368
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT5 keratin 5, type II
LMNB1 lamin B1
LOX lysyl oxidase
LTF lactotransferrin
LY6E lymphocyte antigen 6 complex, locus E
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MGST2 microsomal glutathione S-transferase 2
MICALL1 MICAL-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMI N-myc (and STAT) interactor
PCCB propionyl CoA carboxylase, beta polypeptide
PDGFA platelet-derived growth factor alpha polypeptide
PIR pirin (iron-binding nuclear protein)
PKP4 plakophilin 4
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTX3 pentraxin 3, long
RCN1 reticulocalbin 1, EF-hand calcium binding domain
S100A2 S100 calcium binding protein A2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAGP small cell adhesion glycoprotein
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS3 sorbin and SH3 domain containing 3
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STC2 stanniocalcin 2
STXBP2 syntaxin binding protein 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIM2 tripartite motif containing 2
TYMS thymidylate synthetase
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WIF1 WNT inhibitory factor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon