BRD-A19037878_trichostatin A_HEC108_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-A19037878_trichostatin A_HEC108_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD3 abhydrolase domain containing 3
ACOT7 acyl-CoA thioesterase 7
ACSL3 acyl-CoA synthetase long-chain family member 3
ADD3 adducin 3 (gamma)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANOS1 anosmin 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
CA1 carbonic anhydrase I
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALML4 calmodulin-like 4
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIB1 calcium and integrin binding 1 (calmyrin)
CLIC5 chloride intracellular channel 5
COG5 component of oligomeric golgi complex 5
COL3A1 collagen, type III, alpha 1
CPD carboxypeptidase D
CYB5R1 cytochrome b5 reductase 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHCR7 7-dehydrocholesterol reductase
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
EAF2 ELL associated factor 2
ENAH enabled homolog (Drosophila)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GABARAPL2 GABA(A) receptor-associated protein-like 2
GALC galactosylceramidase
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPD1L glycerol-3-phosphate dehydrogenase 1-like
IDI1 isopentenyl-diphosphate delta isomerase 1
IFT57 intraflagellar transport 57
IGL immunoglobulin lambda locus
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IQGAP2 IQ motif containing GTPase activating protein 2
ITM2A integral membrane protein 2A
KIAA0226L KIAA0226-like
LGMN legumain
LTA4H leukotriene A4 hydrolase
LUM lumican
LY86 lymphocyte antigen 86
MAOB monoamine oxidase B
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGP matrix Gla protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MSRB2 methionine sulfoxide reductase B2
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NLRP2 NLR family, pyrin domain containing 2
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
OAT ornithine aminotransferase
OPTN optineurin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG10 paternally expressed 10
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G15 phospholipase A2, group XV
PNMA2 paraneoplastic Ma antigen 2
POLB polymerase (DNA directed), beta
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPARD peroxisome proliferator-activated receptor delta
PRAF2 PRA1 domain family, member 2
PRKCZ protein kinase C, zeta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
ROGDI rogdi homolog (Drosophila)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SETD3 SET domain containing 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SMYD3 SET and MYND domain containing 3
SNN stannin
SORT1 sortilin 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STK38L serine/threonine kinase 38 like
STX7 syntaxin 7
TBPL1 TBP-like 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMCO1 transmembrane and coiled-coil domains 1
TNS1 tensin 1
TPST2 tyrosylprotein sulfotransferase 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADM adrenomedullin
ANXA1 annexin A1
AQP9 aquaporin 9
BEX1 brain expressed, X-linked 1
CDC14B cell division cycle 14B
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFLAR CASP8 and FADD-like apoptosis regulator
DDIT4 DNA-damage-inducible transcript 4
DEGS1 delta(4)-desaturase, sphingolipid 1
EGFR epidermal growth factor receptor
EIF4A1 eukaryotic translation initiation factor 4A1
EMP3 epithelial membrane protein 3
F5 coagulation factor V (proaccelerin, labile factor)
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXE1 forkhead box E1
FXYD2 FXYD domain containing ion transport regulator 2
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
HMGB2 high mobility group box 2
HOXA10 homeobox A10
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP1 insulin-like growth factor binding protein 1
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KEAP1 kelch-like ECH-associated protein 1
KRT5 keratin 5, type II
LOC100505650 uncharacterized LOC100505650
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OBSL1 obscurin-like 1
PAX8 paired box 8
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PDIA3 protein disulfide isomerase family A, member 3
PDLIM4 PDZ and LIM domain 4
PDZK1 PDZ domain containing 1
PERP PERP, TP53 apoptosis effector
PLK1 polo-like kinase 1
PRR7 proline rich 7 (synaptic)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGES prostaglandin E synthase
QKI QKI, KH domain containing, RNA binding
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL10 ribosomal protein L10
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
SALL1 spalt-like transcription factor 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SLC43A3 solute carrier family 43, member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNAI2 snail family zinc finger 2
SRSF8 serine/arginine-rich splicing factor 8
STAG2 stromal antigen 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
THBS1 thrombospondin 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMEM109 transmembrane protein 109
TNIP1 TNFAIP3 interacting protein 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB20 zinc finger and BTB domain containing 20
ZHX2 zinc fingers and homeoboxes 2