BRD-A19037878_trichostatin A_HCT116_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-A19037878_trichostatin A_HCT116_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARL3 ADP-ribosylation factor-like 3
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C9ORF16 chromosome 9 open reading frame 16
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCDC69 coiled-coil domain containing 69
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CETN2 centrin, EF-hand protein, 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DCTN3 dynactin 3 (p22)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSTN destrin (actin depolymerizing factor)
EDN3 endothelin 3
EZR ezrin
FAM117A family with sequence similarity 117, member A
FN1 fibronectin 1
GALC galactosylceramidase
GLRX glutaredoxin (thioltransferase)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLGA7 golgin A7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK1 hexokinase 1
HLA-B major histocompatibility complex, class I, B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPCAL1 hippocalcin-like 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
INSIG1 insulin induced gene 1
IQGAP2 IQ motif containing GTPase activating protein 2
ISG15 ISG15 ubiquitin-like modifier
ITM2C integral membrane protein 2C
KCTD5 potassium channel tetramerization domain containing 5
LDOC1 leucine zipper, down-regulated in cancer 1
LRRC17 leucine rich repeat containing 17
MAGEB2 melanoma antigen family B2
MGP matrix Gla protein
MGST3 microsomal glutathione S-transferase 3
MMP11 matrix metallopeptidase 11
MSRB1 methionine sulfoxide reductase B1
NOSIP nitric oxide synthase interacting protein
NSDHL NAD(P) dependent steroid dehydrogenase-like
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLA2G15 phospholipase A2, group XV
POR P450 (cytochrome) oxidoreductase
PRAF2 PRA1 domain family, member 2
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PXDN peroxidasin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RBM6 RNA binding motif protein 6
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100P S100 calcium binding protein P
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMYD3 SET and MYND domain containing 3
SRGN serglycin
SSR4 signal sequence receptor, delta
STX1A syntaxin 1A (brain)
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TFF3 trefoil factor 3 (intestinal)
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TM7SF2 transmembrane 7 superfamily member 2
TMCO1 transmembrane and coiled-coil domains 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VIM vimentin
WFS1 Wolfram syndrome 1 (wolframin)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADM adrenomedullin
ADORA2B adenosine A2b receptor
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP9 aquaporin 9
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BTF3 basic transcription factor 3
C8ORF4 chromosome 8 open reading frame 4
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCND1 cyclin D1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CHL1 cell adhesion molecule L1-like
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DST dystonin
DUSP4 dual specificity phosphatase 4
DUT deoxyuridine triphosphatase
ECT2 epithelial cell transforming 2
EFS embryonal Fyn-associated substrate
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB2IP erbb2 interacting protein
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GDF15 growth differentiation factor 15
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX2 glutathione peroxidase 2
HOXA10 homeobox A10
IDO1 indoleamine 2,3-dioxygenase 1
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MRPS30 mitochondrial ribosomal protein S30
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
PBK PDZ binding kinase
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLS3 plastin 3
PNN pinin, desmosome associated protein
PTGES prostaglandin E synthase
PUS7 pseudouridylate synthase 7 (putative)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SENP6 SUMO1/sentrin specific peptidase 6
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNAI2 snail family zinc finger 2
SORBS3 sorbin and SH3 domain containing 3
SPRY2 sprouty homolog 2 (Drosophila)
SRSF11 serine/arginine-rich splicing factor 11
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI2 tissue factor pathway inhibitor 2
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMPO thymopoietin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNPO1 transportin 1
TRIB1 tribbles pseudokinase 1
TRIP6 thyroid hormone receptor interactor 6
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
XPO1 exportin 1
ZBTB38 zinc finger and BTB domain containing 38