BRD-A19037878_trichostatin A_EFO27_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

191 genes differentially expressed following the BRD-A19037878_trichostatin A_EFO27_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADD3 adducin 3 (gamma)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANKRD46 ankyrin repeat domain 46
ARMCX2 armadillo repeat containing, X-linked 2
ASS1 argininosuccinate synthase 1
C14ORF132 chromosome 14 open reading frame 132
C9ORF16 chromosome 9 open reading frame 16
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETN2 centrin, EF-hand protein, 2
COL3A1 collagen, type III, alpha 1
CORO1A coronin, actin binding protein, 1A
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM117A family with sequence similarity 117, member A
G6PD glucose-6-phosphate dehydrogenase
GAS6 growth arrest-specific 6
GLRX glutaredoxin (thioltransferase)
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HRSP12 heat-responsive protein 12
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT57 intraflagellar transport 57
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IL17RB interleukin 17 receptor B
INA internexin neuronal intermediate filament protein, alpha
IQGAP1 IQ motif containing GTPase activating protein 1
ISYNA1 inositol-3-phosphate synthase 1
KCTD5 potassium channel tetramerization domain containing 5
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PLA2G15 phospholipase A2, group XV
PNMA2 paraneoplastic Ma antigen 2
PRSS2 protease, serine, 2 (trypsin 2)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
ROGDI rogdi homolog (Drosophila)
S100A14 S100 calcium binding protein A14
SATB1 SATB homeobox 1
SCPEP1 serine carboxypeptidase 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SST somatostatin
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TOB1 transducer of ERBB2, 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TUFT1 tuftelin 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADIPOQ adiponectin, C1Q and collagen domain containing
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ATF5 activating transcription factor 5
AXL AXL receptor tyrosine kinase
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C1R complement component 1, r subcomponent
C8ORF4 chromosome 8 open reading frame 4
CD8A CD8a molecule
COL4A2 collagen, type IV, alpha 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DENND5A DENN/MADD domain containing 5A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ERBB2 erb-b2 receptor tyrosine kinase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GBE1 glucan (1,4-alpha-), branching enzyme 1
GPR171 G protein-coupled receptor 171
GRIA2 glutamate receptor, ionotropic, AMPA 2
GYG1 glycogenin 1
HBB hemoglobin, beta
HOXC6 homeobox C6
IDO1 indoleamine 2,3-dioxygenase 1
KANK1 KN motif and ankyrin repeat domains 1
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KRT14 keratin 14, type I
LAMB3 laminin, beta 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPY1R neuropeptide Y receptor Y1
OBSL1 obscurin-like 1
PAX8 paired box 8
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
RAD23B RAD23 homolog B (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
S100A2 S100 calcium binding protein A2
SAP30 Sin3A-associated protein, 30kDa
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP1 secreted frizzled-related protein 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMS spermine synthase
SOX17 SRY (sex determining region Y)-box 17
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TBX3 T-box 3
TFF1 trefoil factor 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TRIM14 tripartite motif containing 14
TSC22D1 TSC22 domain family, member 1
TSPAN8 tetraspanin 8
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP22 ubiquitin specific peptidase 22
WEE1 WEE1 G2 checkpoint kinase
ZNF586 zinc finger protein 586