BRD-A19037878_trichostatin A_DV90_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-A19037878_trichostatin A_DV90_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ALDOC aldolase C, fructose-bisphosphate
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COG5 component of oligomeric golgi complex 5
CTSZ cathepsin Z
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOCK9 dedicator of cytokinesis 9
DUSP1 dual specificity phosphatase 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFNB2 ephrin-B2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EZR ezrin
FAM117A family with sequence similarity 117, member A
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOXO1 forkhead box O1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRK5 G protein-coupled receptor kinase 5
HBB hemoglobin, beta
HECA headcase homolog (Drosophila)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LPIN1 lipin 1
LRRN3 leucine rich repeat neuronal 3
MAP7 microtubule-associated protein 7
MLF1 myeloid leukemia factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NLRP2 NLR family, pyrin domain containing 2
NOSIP nitric oxide synthase interacting protein
NPY neuropeptide Y
NUTF2 nuclear transport factor 2
OAT ornithine aminotransferase
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLIN2 perilipin 2
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD9A RAD9 homolog A (S. pombe)
RFTN1 raftlin, lipid raft linker 1
RGS2 regulator of G-protein signaling 2
RIMS3 regulating synaptic membrane exocytosis 3
RRAGC Ras-related GTP binding C
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SELENBP1 selenium binding protein 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SNN stannin
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRPK2 SRSF protein kinase 2
SRPX sushi-repeat containing protein, X-linked
SRSF6 serine/arginine-rich splicing factor 6
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TACC1 transforming, acidic coiled-coil containing protein 1
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TBPL1 TBP-like 1
TKTL1 transketolase-like 1
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VIM vimentin
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ADORA2B adenosine A2b receptor
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ASS1 argininosuccinate synthase 1
BEX1 brain expressed, X-linked 1
CCND1 cyclin D1
CCND2 cyclin D2
COL5A1 collagen, type V, alpha 1
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
EREG epiregulin
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
GANAB glucosidase, alpha; neutral AB
GPI glucose-6-phosphate isomerase
GREM1 gremlin 1, DAN family BMP antagonist
IFITM3 interferon induced transmembrane protein 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGKC immunoglobulin kappa constant
IRS2 insulin receptor substrate 2
ITGB4 integrin, beta 4
JADE2 jade family PHD finger 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MET MET proto-oncogene, receptor tyrosine kinase
MXRA5 matrix-remodelling associated 5
NRIP1 nuclear receptor interacting protein 1
NUP85 nucleoporin 85kDa
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP prolactin-induced protein
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRR7 proline rich 7 (synaptic)
PSCA prostate stem cell antigen
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHOBTB3 Rho-related BTB domain containing 3
RNF167 ring finger protein 167
RPL37A ribosomal protein L37a
S100A2 S100 calcium binding protein A2
SDC1 syndecan 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SETBP1 SET binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC43A3 solute carrier family 43, member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SPATS2L spermatogenesis associated, serine-rich 2-like
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFF1 trefoil factor 1
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM45A transmembrane protein 45A
TNS3 tensin 3
TRIM29 tripartite motif containing 29
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VGLL4 vestigial-like family member 4