BRD-A19037878_trichostatin A_CORL23_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-A19037878_trichostatin A_CORL23_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
AK1 adenylate kinase 1
ALDOC aldolase C, fructose-bisphosphate
ANO10 anoctamin 10
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
C14ORF132 chromosome 14 open reading frame 132
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CCL5 chemokine (C-C motif) ligand 5
CCND3 cyclin D3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLIC3 chloride intracellular channel 3
CORO1A coronin, actin binding protein, 1A
CRLF1 cytokine receptor-like factor 1
CSRP1 cysteine and glycine-rich protein 1
CTSA cathepsin A
CTSZ cathepsin Z
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FKBP1A FK506 binding protein 1A, 12kDa
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLGA7 golgin A7
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSN gelsolin
GUK1 guanylate kinase 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
ITM2A integral membrane protein 2A
KCTD5 potassium channel tetramerization domain containing 5
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT7 keratin 7, type II
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LTA4H leukotriene A4 hydrolase
METRN meteorin, glial cell differentiation regulator
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MPC1 mitochondrial pyruvate carrier 1
MYO6 myosin VI
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NOSIP nitric oxide synthase interacting protein
NPC2 Niemann-Pick disease, type C2
NRGN neurogranin (protein kinase C substrate, RC3)
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLA2G15 phospholipase A2, group XV
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRAF2 PRA1 domain family, member 2
PRKCA protein kinase C, alpha
PRKCZ protein kinase C, zeta
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SCPEP1 serine carboxypeptidase 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMYD3 SET and MYND domain containing 3
SPTSSA serine palmitoyltransferase, small subunit A
SRGN serglycin
STXBP1 syntaxin binding protein 1
STXBP2 syntaxin binding protein 2
TBPL1 TBP-like 1
TBX3 T-box 3
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TNS1 tensin 1
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TST thiosulfate sulfurtransferase (rhodanese)
UNC13B unc-13 homolog B (C. elegans)
VAT1 vesicle amine transport 1
WDR61 WD repeat domain 61
WFS1 Wolfram syndrome 1 (wolframin)
WWC3 WWC family member 3

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ADM adrenomedullin
AGTR1 angiotensin II receptor, type 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA10 annexin A10
AQP9 aquaporin 9
ATF5 activating transcription factor 5
CALB1 calbindin 1, 28kDa
CASD1 CAS1 domain containing 1
CD200 CD200 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFI complement factor I
CFLAR CASP8 and FADD-like apoptosis regulator
CNOT4 CCR4-NOT transcription complex, subunit 4
COG7 component of oligomeric golgi complex 7
CTBP1 C-terminal binding protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYTIP cytohesin 1 interacting protein
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FAM69A family with sequence similarity 69, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
HEATR1 HEAT repeat containing 1
HMGA2 high mobility group AT-hook 2
HOXB2 homeobox B2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
ITGB1BP1 integrin beta 1 binding protein 1
JADE2 jade family PHD finger 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KEAP1 kelch-like ECH-associated protein 1
KLK10 kallikrein-related peptidase 10
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LCN2 lipocalin 2
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MMP10 matrix metallopeptidase 10
MSMB microseminoprotein, beta-
NRIP1 nuclear receptor interacting protein 1
PCDH7 protocadherin 7
PDZK1 PDZ domain containing 1
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PLK2 polo-like kinase 2
PTHLH parathyroid hormone-like hormone
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD3 SMAD family member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UPK1B uroplakin 1B
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZHX2 zinc fingers and homeoboxes 2
ZNF652 zinc finger protein 652