BRD-A19037878_trichostatin A_AGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

269 genes differentially expressed following the BRD-A19037878_trichostatin A_AGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADD3 adducin 3 (gamma)
AHCYL1 adenosylhomocysteinase-like 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ARHGAP29 Rho GTPase activating protein 29
ARL3 ADP-ribosylation factor-like 3
ASMTL acetylserotonin O-methyltransferase-like
BBX bobby sox homolog (Drosophila)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C9ORF16 chromosome 9 open reading frame 16
CALU calumenin
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCNG2 cyclin G2
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLDN3 claudin 3
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CTH cystathionine gamma-lyase
CYLD cylindromatosis (turban tumor syndrome)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EAF2 ELL associated factor 2
EFNB2 ephrin-B2
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EIF5B eukaryotic translation initiation factor 5B
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FBLN5 fibulin 5
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GMCL1 germ cell-less, spermatogenesis associated 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLGA7 golgin A7
GPX3 glutathione peroxidase 3
GRK5 G protein-coupled receptor kinase 5
GSDMB gasdermin B
HEBP1 heme binding protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HIST1H1C histone cluster 1, H1c
HIST1H4C histone cluster 1, H4c
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT20 intraflagellar transport 20
IGFBP5 insulin-like growth factor binding protein 5
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLHL24 kelch-like family member 24
KRT81 keratin 81, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LPIN1 lipin 1
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAN1A1 mannosidase, alpha, class 1A, member 1
MCAM melanoma cell adhesion molecule
MCOLN1 mucolipin 1
MEG3 maternally expressed 3 (non-protein coding)
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MUC2 mucin 2, oligomeric mucus/gel-forming
NBPF10 neuroblastoma breakpoint family, member 10
NCOA3 nuclear receptor coactivator 3
NEU1 sialidase 1 (lysosomal sialidase)
NMT2 N-myristoyltransferase 2
NOSIP nitric oxide synthase interacting protein
NOTCH1 notch 1
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NT5E 5'-nucleotidase, ecto (CD73)
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCSK5 proprotein convertase subtilisin/kexin type 5
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PHKG2 phosphorylase kinase, gamma 2 (testis)
PHTF2 putative homeodomain transcription factor 2
PLA2G15 phospholipase A2, group XV
PLAT plasminogen activator, tissue
PRAF2 PRA1 domain family, member 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PSD3 pleckstrin and Sec7 domain containing 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RASA4 RAS p21 protein activator 4
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
REG1A regenerating islet-derived 1 alpha
REG1B regenerating islet-derived 1 beta
REG3A regenerating islet-derived 3 alpha
RGS10 regulator of G-protein signaling 10
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RND1 Rho family GTPase 1
RNF167 ring finger protein 167
RNF24 ring finger protein 24
ROGDI rogdi homolog (Drosophila)
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGK1 serum/glucocorticoid regulated kinase 1
SLC46A3 solute carrier family 46, member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SRGN serglycin
SST somatostatin
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
TACC1 transforming, acidic coiled-coil containing protein 1
TBPL1 TBP-like 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFF3 trefoil factor 3 (intestinal)
TKTL1 transketolase-like 1
TOB1 transducer of ERBB2, 1
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TUBA1A tubulin, alpha 1a
TUFT1 tuftelin 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDR47 WD repeat domain 47
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZNF131 zinc finger protein 131

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
AHNAK2 AHNAK nucleoprotein 2
AIM2 absent in melanoma 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
C1ORF106 chromosome 1 open reading frame 106
C1ORF116 chromosome 1 open reading frame 116
C7ORF49 chromosome 7 open reading frame 49
CA12 carbonic anhydrase XII
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAPN2 calpain 2, (m/II) large subunit
CKAP4 cytoskeleton-associated protein 4
COA3 cytochrome c oxidase assembly factor 3
COCH cochlin
COMT catechol-O-methyltransferase
CRISP3 cysteine-rich secretory protein 3
CTPS1 CTP synthase 1
DCTD dCMP deaminase
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP3 epithelial membrane protein 3
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FBXW4 F-box and WD repeat domain containing 4
FERMT1 fermitin family member 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GLUL glutamate-ammonia ligase
GSAP gamma-secretase activating protein
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HDGF hepatoma-derived growth factor
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HOPX HOP homeobox
HSPB8 heat shock 22kDa protein 8
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
INTS3 integrator complex subunit 3
IRAK1 interleukin-1 receptor-associated kinase 1
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KLK11 kallikrein-related peptidase 11
KRT18 keratin 18, type I
KRT6A keratin 6A, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LARP1 La ribonucleoprotein domain family, member 1
LMNB2 lamin B2
LRRC41 leucine rich repeat containing 41
LTF lactotransferrin
MAPK13 mitogen-activated protein kinase 13
MICALL1 MICAL-like 1
MRPL57 mitochondrial ribosomal protein L57
MSLN mesothelin
MTMR1 myotubularin related protein 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PMF1 polyamine-modulated factor 1
POGK pogo transposable element with KRAB domain
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
RBMX RNA binding motif protein, X-linked
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RREB1 ras responsive element binding protein 1
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SENP6 SUMO1/sentrin specific peptidase 6
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAGP small cell adhesion glycoprotein
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TCERG1 transcription elongation regulator 1
TLK2 tousled-like kinase 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNNC1 troponin C type 1 (slow)
TRIM29 tripartite motif containing 29
TRIP6 thyroid hormone receptor interactor 6
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
YBX3 Y box binding protein 3
ZBTB20 zinc finger and BTB domain containing 20
ZMYND11 zinc finger, MYND-type containing 11
ZNF512B zinc finger protein 512B