BRD-A19037878_trichostatin A_A673_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

289 genes differentially expressed following the BRD-A19037878_trichostatin A_A673_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ACSL3 acyl-CoA synthetase long-chain family member 3
AK1 adenylate kinase 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARHGAP29 Rho GTPase activating protein 29
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C9ORF16 chromosome 9 open reading frame 16
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CCNG2 cyclin G2
CD24 CD24 molecule
CD47 CD47 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP70 centrosomal protein 70kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKM creatine kinase, muscle
CLU clusterin
COG5 component of oligomeric golgi complex 5
CORO1A coronin, actin binding protein, 1A
CPM carboxypeptidase M
CREG1 cellular repressor of E1A-stimulated genes 1
CTSW cathepsin W
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5R1 cytochrome b5 reductase 1
CYBB cytochrome b-245, beta polypeptide
CYLD cylindromatosis (turban tumor syndrome)
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBLN5 fibulin 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GCA grancalcin, EF-hand calcium binding protein
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H4H histone cluster 1, H4h
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HPCAL1 hippocalcin-like 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL17RB interleukin 17 receptor B
IQCG IQ motif containing G
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
JUNB jun B proto-oncogene
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLHL41 kelch-like family member 41
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIPA lipase A, lysosomal acid, cholesterol esterase
LUM lumican
MAGEB2 melanoma antigen family B2
MCOLN1 mucolipin 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEG3 maternally expressed 3 (non-protein coding)
MFSD10 major facilitator superfamily domain containing 10
MIR22HG MIR22 host gene
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLF1 myeloid leukemia factor 1
MOSPD1 motile sperm domain containing 1
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MX1 MX dynamin-like GTPase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEB nebulin
NEFH neurofilament, heavy polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NLRP2 NLR family, pyrin domain containing 2
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
P4HB prolyl 4-hydroxylase, beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS21 protease, serine, 21 (testisin)
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RSAD2 radical S-adenosyl methionine domain containing 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRGN serglycin
SRSF6 serine/arginine-rich splicing factor 6
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STAB1 stabilin 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STXBP1 syntaxin binding protein 1
TKTL1 transketolase-like 1
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TRIM36 tripartite motif containing 36
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
TYROBP TYRO protein tyrosine kinase binding protein
VCL vinculin
VNN1 vanin 1
VWA5A von Willebrand factor A domain containing 5A
WBP5 WW domain binding protein 5
WFS1 Wolfram syndrome 1 (wolframin)
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACAN aggrecan
AKR1C1 aldo-keto reductase family 1, member C1
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARID1A AT rich interactive domain 1A (SWI-like)
AUTS2 autism susceptibility candidate 2
BEX1 brain expressed, X-linked 1
BTG3 BTG family, member 3
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CD200 CD200 molecule
CD58 CD58 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CKAP4 cytoskeleton-associated protein 4
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CTPS1 CTP synthase 1
CYTIP cytohesin 1 interacting protein
DARS aspartyl-tRNA synthetase
DIAPH2 diaphanous-related formin 2
DST dystonin
EFS embryonal Fyn-associated substrate
F5 coagulation factor V (proaccelerin, labile factor)
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FAS Fas cell surface death receptor
FGF13 fibroblast growth factor 13
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS2 growth arrest-specific 2
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
GSTO1 glutathione S-transferase omega 1
HDDC2 HD domain containing 2
HDGF hepatoma-derived growth factor
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXB2 homeobox B2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IPO5 importin 5
IVNS1ABP influenza virus NS1A binding protein
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KPNB1 karyopherin (importin) beta 1
LIMS1 LIM and senescent cell antigen-like domains 1
LRRC41 leucine rich repeat containing 41
MAPK6 mitogen-activated protein kinase 6
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
MFAP5 microfibrillar associated protein 5
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME4 NME/NM23 nucleoside diphosphate kinase 4
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PHIP pleckstrin homology domain interacting protein
PIP prolactin-induced protein
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
QKI QKI, KH domain containing, RNA binding
RAB13 RAB13, member RAS oncogene family
RBMX RNA binding motif protein, X-linked
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGCC regulator of cell cycle
SELL selectin L
SENP6 SUMO1/sentrin specific peptidase 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX2 SRY (sex determining region Y)-box 2
SPRY2 sprouty homolog 2 (Drosophila)
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCERG1 transcription elongation regulator 1
TCF12 transcription factor 12
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLK2 tousled-like kinase 2
TMEM47 transmembrane protein 47
TNC tenascin C
TRIB1 tribbles pseudokinase 1
TYMS thymidylate synthetase
UBA2 ubiquitin-like modifier activating enzyme 2
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCAN versican
WEE1 WEE1 G2 checkpoint kinase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZHX2 zinc fingers and homeoboxes 2
ZMYND11 zinc finger, MYND-type containing 11