BRD-A18917088_ESTRADIOL_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-A18917088_ESTRADIOL_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ADGRG2 adhesion G protein-coupled receptor G2
ARMCX3 armadillo repeat containing, X-linked 3
BBX bobby sox homolog (Drosophila)
C3ORF14 chromosome 3 open reading frame 14
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL9A3 collagen, type IX, alpha 3
CRABP1 cellular retinoic acid binding protein 1
CSK c-src tyrosine kinase
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF5A eukaryotic translation initiation factor 5A
FAM107A family with sequence similarity 107, member A
FOXO3 forkhead box O3
GLRX glutaredoxin (thioltransferase)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPM6B glycoprotein M6B
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGF1R insulin-like growth factor 1 receptor
INPP1 inositol polyphosphate-1-phosphatase
KAT6B K(lysine) acetyltransferase 6B
KIAA1324 KIAA1324
LRRC16A leucine rich repeat containing 16A
MAGED1 melanoma antigen family D1
MCOLN1 mucolipin 1
MTSS1 metastasis suppressor 1
NDNF neuron-derived neurotrophic factor
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PADI2 peptidyl arginine deiminase, type II
PBX1 pre-B-cell leukemia homeobox 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIAS1 protein inhibitor of activated STAT, 1
PLIN2 perilipin 2
PROM1 prominin 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RYBP RING1 and YY1 binding protein
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPDEF SAM pointed domain containing ETS transcription factor
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SYBU syntabulin (syntaxin-interacting)
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMX4 thioredoxin-related transmembrane protein 4
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRE5 adhesion G protein-coupled receptor E5
CBX6 chromobox homolog 6
CCL20 chemokine (C-C motif) ligand 20
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL6A3 collagen, type VI, alpha 3
CRISP3 cysteine-rich secretory protein 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL9 chemokine (C-X-C motif) ligand 9
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GBP1 guanylate binding protein 1, interferon-inducible
GIMAP4 GTPase, IMAP family member 4
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRWD1 glutamate-rich WD repeat containing 1
HEATR1 HEAT repeat containing 1
HLA-C major histocompatibility complex, class I, C
HOPX HOP homeobox
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
JUP junction plakoglobin
LAMA4 laminin, alpha 4
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
MEF2C myocyte enhancer factor 2C
MET MET proto-oncogene, receptor tyrosine kinase
NHP2 NHP2 ribonucleoprotein
NID2 nidogen 2 (osteonidogen)
NOP16 NOP16 nucleolar protein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLBD1 phospholipase B domain containing 1
PLS3 plastin 3
PNP purine nucleoside phosphorylase
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRR7 proline rich 7 (synaptic)
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SRM spermidine synthase
ST7 suppression of tumorigenicity 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TKT transketolase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TP53 tumor protein p53
TPM2 tropomyosin 2 (beta)
TSPAN8 tetraspanin 8
TXNRD1 thioredoxin reductase 1
TYRP1 tyrosinase-related protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCRH ubiquinol-cytochrome c reductase hinge protein
VNN1 vanin 1
WDR3 WD repeat domain 3