BRD-A18917088_ESTRADIOL_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-A18917088_ESTRADIOL_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACSL3 acyl-CoA synthetase long-chain family member 3
AREG amphiregulin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CARD10 caspase recruitment domain family, member 10
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLDN8 claudin 8
COL4A5 collagen, type IV, alpha 5
CWH43 cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DST dystonin
ELOVL5 ELOVL fatty acid elongase 5
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FAM114A1 family with sequence similarity 114, member A1
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
HOMER2 homer scaffolding protein 2
IL1R1 interleukin 1 receptor, type I
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
KRT23 keratin 23, type I
LAMP2 lysosomal-associated membrane protein 2
LIMK2 LIM domain kinase 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MYOF myoferlin
NEBL nebulette
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
PPAP2B phosphatidic acid phosphatase type 2B
RAP1GAP RAP1 GTPase activating protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SERINC5 serine incorporator 5
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPINT1 serine peptidase inhibitor, Kunitz type 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHCY adenosylhomocysteinase
ASF1B anti-silencing function 1B histone chaperone
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
CCL19 chemokine (C-C motif) ligand 19
CD320 CD320 molecule
CD81 CD81 molecule
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CHEK2 checkpoint kinase 2
CLU clusterin
CSE1L CSE1 chromosome segregation 1-like (yeast)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM13A family with sequence similarity 13, member A
FANCI Fanconi anemia, complementation group I
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGFBP3 insulin-like growth factor binding protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KRT13 keratin 13, type I
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LY6E lymphocyte antigen 6 complex, locus E
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MRPS2 mitochondrial ribosomal protein S2
MTA1 metastasis associated 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPM3 nucleophosmin/nucleoplasmin 3
OLFM1 olfactomedin 1
OXCT1 3-oxoacid CoA transferase 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCNA proliferating cell nuclear antigen
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT1 protein arginine methyltransferase 1
RHOB ras homolog family member B
RNASEH2A ribonuclease H2, subunit A
RPL22 ribosomal protein L22
RPL36 ribosomal protein L36
RPS2 ribosomal protein S2
RPS4Y1 ribosomal protein S4, Y-linked 1
RUVBL2 RuvB-like AAA ATPase 2
SEH1L SEH1-like (S. cerevisiae)
SEPW1 selenoprotein W, 1
SMAD1 SMAD family member 1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPATA20 spermatogenesis associated 20
SRSF7 serine/arginine-rich splicing factor 7
ST7 suppression of tumorigenicity 7
TFAM transcription factor A, mitochondrial
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TRIM28 tripartite motif containing 28
TRIP13 thyroid hormone receptor interactor 13
TRIP6 thyroid hormone receptor interactor 6
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C