BRD-A18917088_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-A18917088_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADORA2B adenosine A2b receptor
ANPEP alanyl (membrane) aminopeptidase
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CD52 CD52 molecule
CDC25B cell division cycle 25B
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSTA cystatin A (stefin A)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FAM129A family with sequence similarity 129, member A
FASTKD5 FAST kinase domains 5
FILIP1L filamin A interacting protein 1-like
FRY furry homolog (Drosophila)
GAS6 growth arrest-specific 6
GRB10 growth factor receptor-bound protein 10
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LINC00341 long intergenic non-protein coding RNA 341
LYZ lysozyme
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCUR1 mitochondrial calcium uniporter regulator 1
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
PCCB propionyl CoA carboxylase, beta polypeptide
PDGFC platelet derived growth factor C
PID1 phosphotyrosine interaction domain containing 1
PLXNC1 plexin C1
PSAT1 phosphoserine aminotransferase 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TFRC transferrin receptor
THBS1 thrombospondin 1
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD10 ankyrin repeat domain 10
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BIN1 bridging integrator 1
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C1R complement component 1, r subcomponent
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CLIC3 chloride intracellular channel 3
COL4A2 collagen, type IV, alpha 2
DLD dihydrolipoamide dehydrogenase
EDN3 endothelin 3
FBLN1 fibulin 1
FSTL1 follistatin-like 1
FXYD3 FXYD domain containing ion transport regulator 3
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSTP1 glutathione S-transferase pi 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IRS1 insulin receptor substrate 1
LDHB lactate dehydrogenase B
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LPCAT1 lysophosphatidylcholine acyltransferase 1
LYPLA1 lysophospholipase I
MALL mal, T-cell differentiation protein-like
MAN2B1 mannosidase, alpha, class 2B, member 1
MCM6 minichromosome maintenance complex component 6
METRN meteorin, glial cell differentiation regulator
MRPL19 mitochondrial ribosomal protein L19
MTCL1 microtubule crosslinking factor 1
MXRA7 matrix-remodelling associated 7
MYH10 myosin, heavy chain 10, non-muscle
NMT1 N-myristoyltransferase 1
NUTF2 nuclear transport factor 2
PAM peptidylglycine alpha-amidating monooxygenase
PCDH9 protocadherin 9
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK2 polo-like kinase 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RHOB ras homolog family member B
SCRN1 secernin 1
SMAD3 SMAD family member 3
SORBS2 sorbin and SH3 domain containing 2
SRSF6 serine/arginine-rich splicing factor 6
STC1 stanniocalcin 1
TFPI2 tissue factor pathway inhibitor 2
WIF1 WNT inhibitory factor 1
ZNF22 zinc finger protein 22