BRD-A18763547_-666_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-A18763547_-666_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACACA acetyl-CoA carboxylase alpha
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR2 adiponectin receptor 2
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOC aldolase C, fructose-bisphosphate
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BHLHE40 basic helix-loop-helix family, member e40
C10ORF10 chromosome 10 open reading frame 10
C14ORF1 chromosome 14 open reading frame 1
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CARS cysteinyl-tRNA synthetase
CAST calpastatin
CCL2 chemokine (C-C motif) ligand 2
CCNG2 cyclin G2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CETN2 centrin, EF-hand protein, 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIDEC cell death-inducing DFFA-like effector c
CLIC4 chloride intracellular channel 4
CPA3 carboxypeptidase A3 (mast cell)
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DPT dermatopontin
EBP emopamil binding protein (sterol isomerase)
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
EMP3 epithelial membrane protein 3
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FLNA filamin A, alpha
FMO2 flavin containing monooxygenase 2 (non-functional)
FOXO3 forkhead box O3
G6PD glucose-6-phosphate dehydrogenase
GARS glycyl-tRNA synthetase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
JUNB jun B proto-oncogene
KAT6B K(lysine) acetyltransferase 6B
KDM4B lysine (K)-specific demethylase 4B
KRT81 keratin 81, type II
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LPL lipoprotein lipase
LRRC15 leucine rich repeat containing 15
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MARS methionyl-tRNA synthetase
MCTP1 multiple C2 domains, transmembrane 1
MICA MHC class I polypeptide-related sequence A
MKNK2 MAP kinase interacting serine/threonine kinase 2
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MVD mevalonate (diphospho) decarboxylase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NSDHL NAD(P) dependent steroid dehydrogenase-like
OPTN optineurin
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PER1 period circadian clock 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIR pirin (iron-binding nuclear protein)
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PRKCH protein kinase C, eta
PSAT1 phosphoserine aminotransferase 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SARS seryl-tRNA synthetase
SC5D sterol-C5-desaturase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35F2 solute carrier family 35, member F2
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SQLE squalene epoxidase
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SSR4 signal sequence receptor, delta
STXBP1 syntaxin binding protein 1
TIMP1 TIMP metallopeptidase inhibitor 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TULP3 tubby like protein 3
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WBP2 WW domain binding protein 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
ARG1 arginase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPH aspartate beta-hydroxylase
BEX4 brain expressed, X-linked 4
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNE2 cyclin E2
CD53 CD53 molecule
CDC5L cell division cycle 5-like
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CKLF chemokine-like factor
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COTL1 coactosin-like F-actin binding protein 1
CP ceruloplasmin (ferroxidase)
CPQ carboxypeptidase Q
CTGF connective tissue growth factor
CYBA cytochrome b-245, alpha polypeptide
EIF5A eukaryotic translation initiation factor 5A
FYB FYN binding protein
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
HCLS1 hematopoietic cell-specific Lyn substrate 1
HES1 hes family bHLH transcription factor 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
JAM3 junctional adhesion molecule 3
KRT10 keratin 10, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LXN latexin
MAN1C1 mannosidase, alpha, class 1C, member 1
MCAM melanoma cell adhesion molecule
MMP8 matrix metallopeptidase 8
MYCBP MYC binding protein
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP56 NOP56 ribonucleoprotein
NUTF2 nuclear transport factor 2
PDLIM2 PDZ and LIM domain 2 (mystique)
PLAT plasminogen activator, tissue
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB25 RAB25, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RND3 Rho family GTPase 3
RPA2 replication protein A2, 32kDa
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SATB1 SATB homeobox 1
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SEPW1 selenoprotein W, 1
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLIRP SRA stem-loop interacting RNA binding protein
SLPI secretory leukocyte peptidase inhibitor
SOX11 SRY (sex determining region Y)-box 11
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM45A transmembrane protein 45A
TMX1 thioredoxin-related transmembrane protein 1
TUBB6 tubulin, beta 6 class V
UGDH UDP-glucose 6-dehydrogenase
WWTR1 WW domain containing transcription regulator 1