BRD-A18763547_-666_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-A18763547_-666_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANPEP alanyl (membrane) aminopeptidase
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
CA2 carbonic anhydrase II
CALML5 calmodulin-like 5
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
G6PD glucose-6-phosphate dehydrogenase
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSIG1 insulin induced gene 1
KAT6B K(lysine) acetyltransferase 6B
KCNK1 potassium channel, two pore domain subfamily K, member 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MMP1 matrix metallopeptidase 1
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MYBPC1 myosin binding protein C, slow type
MYH11 myosin, heavy chain 11, smooth muscle
NEB nebulin
NPC1 Niemann-Pick disease, type C1
NRGN neurogranin (protein kinase C substrate, RC3)
NSDHL NAD(P) dependent steroid dehydrogenase-like
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
RBPMS RNA binding protein with multiple splicing
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBD thrombomodulin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
BCLAF1 BCL2-associated transcription factor 1
BEX1 brain expressed, X-linked 1
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHI3L2 chitinase 3-like 2
CHL1 cell adhesion molecule L1-like
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DUSP14 dual specificity phosphatase 14
FAM216A family with sequence similarity 216, member A
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GOLGA8A golgin A8 family, member A
GSPT1 G1 to S phase transition 1
KIAA0020 KIAA0020
LTF lactotransferrin
MRPS2 mitochondrial ribosomal protein S2
MYH10 myosin, heavy chain 10, non-muscle
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
PEG3 paternally expressed 3
PKN2 protein kinase N2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP1B ribosomal RNA processing 1B
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SRSF7 serine/arginine-rich splicing factor 7
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFRC transferrin receptor
TM9SF3 transmembrane 9 superfamily member 3
TRIP13 thyroid hormone receptor interactor 13
WDR3 WD repeat domain 3