BRD-A18763547_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-A18763547_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACSL1 acyl-CoA synthetase long-chain family member 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BHLHE40 basic helix-loop-helix family, member e40
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CERS6 ceramide synthase 6
CES1 carboxylesterase 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRDL1 chordin-like 1
CPB1 carboxypeptidase B1 (tissue)
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DIXDC1 DIX domain containing 1
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM60A family with sequence similarity 60, member A
FAM63A family with sequence similarity 63, member A
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FMO3 flavin containing monooxygenase 3
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGB1 golgin B1
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IL6 interleukin 6
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KDM3A lysine (K)-specific demethylase 3A
KIAA1598
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT15 keratin 15, type I
LDLR low density lipoprotein receptor
MAGED2 melanoma antigen family D2
MGP matrix Gla protein
MLPH melanophilin
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2C phosphatidic acid phosphatase type 2C
PPP1R15A protein phosphatase 1, regulatory subunit 15A
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOB ras homolog family member B
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCYL3 SCY1-like 3 (S. cerevisiae)
SH3BP4 SH3-domain binding protein 4
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
SREBF1 sterol regulatory element binding transcription factor 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TGIF1 TGFB-induced factor homeobox 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
VCAN versican
VEGFA vascular endothelial growth factor A
WFDC2 WAP four-disulfide core domain 2
ZNF217 zinc finger protein 217

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK2 AHNAK nucleoprotein 2
B3GNT1
C14ORF2 chromosome 14 open reading frame 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CLTB clathrin, light chain B
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUOX2 dual oxidase 2
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FERMT1 fermitin family member 1
GBP1 guanylate binding protein 1, interferon-inducible
HHEX hematopoietically expressed homeobox
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
MAT2A methionine adenosyltransferase II, alpha
MIR22HG MIR22 host gene
MXRA7 matrix-remodelling associated 7
NOP16 NOP16 nucleolar protein
PEX11A peroxisomal biogenesis factor 11 alpha
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLAC8 placenta-specific 8
PSCA prostate stem cell antigen
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SPINK1 serine peptidase inhibitor, Kazal type 1
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBB4B tubulin, beta 4B class IVb
UBE2N ubiquitin-conjugating enzyme E2N
USP46 ubiquitin specific peptidase 46
WFS1 Wolfram syndrome 1 (wolframin)