BRD-A18763547_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-A18763547_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADGRG1 adhesion G protein-coupled receptor G1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CA12 carbonic anhydrase XII
CCNG2 cyclin G2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CYTH1 cytohesin 1
DCTN2 dynactin 2 (p50)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EIF1 eukaryotic translation initiation factor 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPS8 epidermal growth factor receptor pathway substrate 8
FAM117A family with sequence similarity 117, member A
FOXD1 forkhead box D1
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GAREM GRB2 associated, regulator of MAPK1
GARS glycyl-tRNA synthetase
GTF2IRD1 GTF2I repeat domain containing 1
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IFI44L interferon-induced protein 44-like
IFRD1 interferon-related developmental regulator 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1B microtubule-associated protein 1B
MAST4 microtubule associated serine/threonine kinase family member 4
MFAP5 microfibrillar associated protein 5
MSX1 msh homeobox 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MYO10 myosin X
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PCSK5 proprotein convertase subtilisin/kexin type 5
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLVAP plasmalemma vesicle associated protein
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
RND3 Rho family GTPase 3
RNF167 ring finger protein 167
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A2 solute carrier family 38, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
SST somatostatin
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TKTL1 transketolase-like 1
TLK2 tousled-like kinase 2
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein
ZNF423 zinc finger protein 423
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APMAP adipocyte plasma membrane associated protein
BCHE butyrylcholinesterase
CALD1 caldesmon 1
CCNB2 cyclin B2
CCND1 cyclin D1
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
COCH cochlin
COL4A5 collagen, type IV, alpha 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HMGN3 high mobility group nucleosomal binding domain 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
IL1RAP interleukin 1 receptor accessory protein
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KRT18 keratin 18, type I
LUM lumican
MAT2A methionine adenosyltransferase II, alpha
MTCL1 microtubule crosslinking factor 1
MXRA7 matrix-remodelling associated 7
MYCBP MYC binding protein
NNMT nicotinamide N-methyltransferase
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PDIA6 protein disulfide isomerase family A, member 6
PON2 paraoxonase 2
RFC3 replication factor C (activator 1) 3, 38kDa
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SEPP1 selenoprotein P, plasma, 1
SPP1 secreted phosphoprotein 1
SYNGR2 synaptogyrin 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S