BRD-A18763547_-666_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-A18763547_-666_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ACSL1 acyl-CoA synthetase long-chain family member 1
ADCK3 aarF domain containing kinase 3
ARG2 arginase 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
CD24 CD24 molecule
CD93 CD93 molecule
CFB complement factor B
CLDN3 claudin 3
CPE carboxypeptidase E
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DES desmin
DHCR7 7-dehydrocholesterol reductase
EDNRA endothelin receptor type A
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGR FGR proto-oncogene, Src family tyrosine kinase
FHL1 four and a half LIM domains 1
GREB1 growth regulation by estrogen in breast cancer 1
GSN gelsolin
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IL1RN interleukin 1 receptor antagonist
INSR insulin receptor
IRS2 insulin receptor substrate 2
ITGA7 integrin, alpha 7
KDM5D lysine (K)-specific demethylase 5D
KLF11 Kruppel-like factor 11
LAMA4 laminin, alpha 4
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
NFIL3 nuclear factor, interleukin 3 regulated
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
NSDHL NAD(P) dependent steroid dehydrogenase-like
OSBPL10 oxysterol binding protein-like 10
OSR2 odd-skipped related transciption factor 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PARP8 poly (ADP-ribose) polymerase family, member 8
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PODXL podocalyxin-like
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PRUNE2 prune homolog 2 (Drosophila)
RBM47 RNA binding motif protein 47
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RTN1 reticulon 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SVIL supervillin
TFF1 trefoil factor 1
TKT transketolase
TMCC1 transmembrane and coiled-coil domain family 1
TRIB1 tribbles pseudokinase 1
TRIM16 tripartite motif containing 16
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
AK1 adenylate kinase 1
CDC25A cell division cycle 25A
COL4A5 collagen, type IV, alpha 5
COL9A3 collagen, type IX, alpha 3
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CXCL2 chemokine (C-X-C motif) ligand 2
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HOPX HOP homeobox
HOXA5 homeobox A5
HSPB11 heat shock protein family B (small), member 11
LDHB lactate dehydrogenase B
MBP myelin basic protein
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PLK1 polo-like kinase 1
PLS3 plastin 3
RGS2 regulator of G-protein signaling 2
RPS5 ribosomal protein S5
SFTPB surfactant protein B
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TANK TRAF family member-associated NFKB activator
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
XIST X inactive specific transcript (non-protein coding)