BRD-A18763547_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

246 genes differentially expressed following the BRD-A18763547_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
ACKR3 atypical chemokine receptor 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCK3 aarF domain containing kinase 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP9A ATPase, class II, type 9A
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CLDN3 claudin 3
CLEC11A C-type lectin domain family 11, member A
CLEC2B C-type lectin domain family 2, member B
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP6 dual specificity phosphatase 6
EPS8 epidermal growth factor receptor pathway substrate 8
EZR ezrin
FAM102A family with sequence similarity 102, member A
FAM46A family with sequence similarity 46, member A
FGFR1 fibroblast growth factor receptor 1
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
FOXO4 forkhead box O4
GAB2 GRB2-associated binding protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GAREM GRB2 associated, regulator of MAPK1
GARS glycyl-tRNA synthetase
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GLUL glutamate-ammonia ligase
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
INSR insulin receptor
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHDC2 kelch domain containing 2
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
MGLL monoglyceride lipase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MKRN1 makorin ring finger protein 1
MNT MAX network transcriptional repressor
MSMO1 methylsterol monooxygenase 1
MXI1 MAX interactor 1, dimerization protein
N4BP2L1 NEDD4 binding protein 2-like 1
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLA2G16 phospholipase A2, group XVI
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PTN pleiotrophin
PXDN peroxidasin
RAB9A RAB9A, member RAS oncogene family
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP2 RAP1 GTPase activating protein 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC22A18 solute carrier family 22, member 18
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SOX4 SRY (sex determining region Y)-box 4
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TBC1D15 TBC1 domain family, member 15
TBL1X transducin (beta)-like 1X-linked
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TKT transketolase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UBXN7 UBX domain protein 7
UGDH UDP-glucose 6-dehydrogenase
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
XYLT1 xylosyltransferase I
YARS tyrosyl-tRNA synthetase
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ALCAM activated leukocyte cell adhesion molecule
ALG6 ALG6, alpha-1,3-glucosyltransferase
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APMAP adipocyte plasma membrane associated protein
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCHE butyrylcholinesterase
BDNF brain-derived neurotrophic factor
BEX1 brain expressed, X-linked 1
C3 complement component 3
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCND1 cyclin D1
CD200 CD200 molecule
CD24 CD24 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CNN1 calponin 1, basic, smooth muscle
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COL5A2 collagen, type V, alpha 2
COX11 COX11 cytochrome c oxidase copper chaperone
CP ceruloplasmin (ferroxidase)
CROT carnitine O-octanoyltransferase
CSRP2 cysteine and glycine-rich protein 2
CTSC cathepsin C
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
CYR61 cysteine-rich, angiogenic inducer, 61
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
EXTL2 exostosin-like glycosyltransferase 2
FILIP1L filamin A interacting protein 1-like
FKBP14 FK506 binding protein 14, 22 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLIPR1 GLI pathogenesis-related 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HACD1 3-hydroxyacyl-CoA dehydratase 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGN3 high mobility group nucleosomal binding domain 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ITGA6 integrin, alpha 6
KRT6A keratin 6A, type II
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LSM1 LSM1, U6 small nuclear RNA associated
LYPLA1 lysophospholipase I
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED1 melanoma antigen family D1
MAP2K6 mitogen-activated protein kinase kinase 6
MAT2A methionine adenosyltransferase II, alpha
MGST2 microsomal glutathione S-transferase 2
MOK MOK protein kinase
MTCL1 microtubule crosslinking factor 1
MYCBP MYC binding protein
MYD88 myeloid differentiation primary response 88
NRIP1 nuclear receptor interacting protein 1
NSF N-ethylmaleimide-sensitive factor
OXTR oxytocin receptor
PALLD palladin, cytoskeletal associated protein
PCP4 Purkinje cell protein 4
PCTP phosphatidylcholine transfer protein
PDLIM5 PDZ and LIM domain 5
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PON2 paraoxonase 2
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RER1 retention in endoplasmic reticulum sorting receptor 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SORD sorbitol dehydrogenase
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SPTSSA serine palmitoyltransferase, small subunit A
SRSF2 serine/arginine-rich splicing factor 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM14A transmembrane protein 14A
TMEM14B transmembrane protein 14B
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TMEM5 transmembrane protein 5
TNS3 tensin 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN6 tetraspanin 6
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WDR61 WD repeat domain 61
WNT5A wingless-type MMTV integration site family, member 5A