BRD-A18763547_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

345 genes differentially expressed following the BRD-A18763547_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADGRE5 adhesion G protein-coupled receptor E5
ADGRG1 adhesion G protein-coupled receptor G1
AKAP13 A kinase (PRKA) anchor protein 13
AMDHD2 amidohydrolase domain containing 2
APOD apolipoprotein D
AREG amphiregulin
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AXIN1 axin 1
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC28A coiled-coil domain containing 28A
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLGN calmegin
COMP cartilage oligomeric matrix protein
CTBP2 C-terminal binding protein 2
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EPAS1 endothelial PAS domain protein 1
F11R F11 receptor
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FAM134A family with sequence similarity 134, member A
FBN1 fibrillin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GAB2 GRB2-associated binding protein 2
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOLGB1 golgin B1
GOLM1 golgi membrane protein 1
GRB10 growth factor receptor-bound protein 10
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRN granulin
GSN gelsolin
GTPBP2 GTP binding protein 2
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HDAC5 histone deacetylase 5
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL6 interleukin 6
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUND jun D proto-oncogene
JUP junction plakoglobin
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KIF13B kinesin family member 13B
KLF11 Kruppel-like factor 11
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LIN37 lin-37 DREAM MuvB core complex component
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MICALL1 MICAL-like 1
MME membrane metallo-endopeptidase
MNT MAX network transcriptional repressor
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
NAV2 neuron navigator 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFE2L1 nuclear factor, erythroid 2-like 1
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
OSBPL10 oxysterol binding protein-like 10
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFA platelet-derived growth factor alpha polypeptide
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLA2G16 phospholipase A2, group XVI
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
POU2AF1 POU class 2 associating factor 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYGB phosphorylase, glycogen; brain
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS3 regulator of G-protein signaling 3
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNF167 ring finger protein 167
RRAGC Ras-related GTP binding C
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPB surfactant protein B
SIDT2 SID1 transmembrane family, member 2
SIK3 SIK family kinase 3
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX4 SRY (sex determining region Y)-box 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQLE squalene epoxidase
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
ST18 suppression of tumorigenicity 18, zinc finger
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TFE3 transcription factor binding to IGHM enhancer 3
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNIP1 TNFAIP3 interacting protein 1
TPBG trophoblast glycoprotein
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WIPF2 WAS/WASL interacting protein family, member 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
ALG6 ALG6, alpha-1,3-glucosyltransferase
ALG8 ALG8, alpha-1,3-glucosyltransferase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
B3GNT1
BCHE butyrylcholinesterase
C12ORF29 chromosome 12 open reading frame 29
C1S complement component 1, s subcomponent
C3 complement component 3
CALD1 caldesmon 1
CASP6 caspase 6, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCND3 cyclin D3
CCNF cyclin F
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CFI complement factor I
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CNN3 calponin 3, acidic
COG2 component of oligomeric golgi complex 2
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)
CP ceruloplasmin (ferroxidase)
CSRP2 cysteine and glycine-rich protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CYB5A cytochrome b5 type A (microsomal)
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ECI2 enoyl-CoA delta isomerase 2
EDN1 endothelin 1
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD1 FAST kinase domains 1
FASTKD5 FAST kinase domains 5
FBLN5 fibulin 5
FERMT1 fermitin family member 1
FJX1 four jointed box 1 (Drosophila)
FRZB frizzled-related protein
FYB FYN binding protein
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
GTF2A2 general transcription factor IIA, 2, 12kDa
GTF2H5 general transcription factor IIH, polypeptide 5
HDAC2 histone deacetylase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HP haptoglobin
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IPW imprinted in Prader-Willi syndrome (non-protein coding)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LMNB1 lamin B1
LSM1 LSM1, U6 small nuclear RNA associated
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAOB monoamine oxidase B
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
MFF mitochondrial fission factor
MPHOSPH6 M-phase phosphoprotein 6
MPHOSPH9 M-phase phosphoprotein 9
MYCBP MYC binding protein
NAP1L1 nucleosome assembly protein 1-like 1
NELL2 NEL-like 2 (chicken)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP16 NOP16 nucleolar protein
NSG1 neuron specific gene family member 1
NT5DC2 5'-nucleotidase domain containing 2
NUP107 nucleoporin 107kDa
PA2G4 proliferation-associated 2G4, 38kDa
PAK1IP1 PAK1 interacting protein 1
PDCD2 programmed cell death 2
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PON2 paraoxonase 2
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
RBP1 retinol binding protein 1, cellular
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RPA2 replication protein A2, 32kDa
RPL26L1 ribosomal protein L26-like 1
RRM2 ribonucleotide reductase M2
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDHAF3 succinate dehydrogenase complex assembly factor 3
SFPQ splicing factor proline/glutamine-rich
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNX6 sorting nexin 6
SORD sorbitol dehydrogenase
SOX11 SRY (sex determining region Y)-box 11
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
SUB1 SUB1 homolog (S. cerevisiae)
TFDP1 transcription factor Dp-1
TMEM14A transmembrane protein 14A
TMEM14B transmembrane protein 14B
TRA2B transformer 2 beta homolog (Drosophila)
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit
WDR3 WD repeat domain 3
WDR61 WD repeat domain 61