BRD-A18763547_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

149 genes differentially expressed following the BRD-A18763547_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRABP2 cellular retinoic acid binding protein 2
CRISP3 cysteine-rich secretory protein 3
CTSD cathepsin D
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DHCR7 7-dehydrocholesterol reductase
DUSP4 dual specificity phosphatase 4
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GM2A GM2 ganglioside activator
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IPO13 importin 13
IRF9 interferon regulatory factor 9
JUN jun proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF4 Kruppel-like factor 4 (gut)
LAMP2 lysosomal-associated membrane protein 2
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MGLL monoglyceride lipase
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NPC1 Niemann-Pick disease, type C1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NT5E 5'-nucleotidase, ecto (CD73)
PLCB4 phospholipase C, beta 4
PRUNE2 prune homolog 2 (Drosophila)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRK protein tyrosine phosphatase, receptor type, K
RRBP1 ribosome binding protein 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORT1 sortilin 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
SQLE squalene epoxidase
SRPX sushi-repeat containing protein, X-linked
SSFA2 sperm specific antigen 2
STK26 serine/threonine protein kinase 26
SYNJ2 synaptojanin 2
SYT1 synaptotagmin I
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNS1 tensin 1
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
AK1 adenylate kinase 1
AURKB aurora kinase B
BAD BCL2-associated agonist of cell death
BIRC5 baculoviral IAP repeat containing 5
C8ORF4 chromosome 8 open reading frame 4
CACYBP calcyclin binding protein
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CENPU centromere protein U
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
F2R coagulation factor II (thrombin) receptor
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GPX3 glutathione peroxidase 3
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HMGB2 high mobility group box 2
HOXC6 homeobox C6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIAA0101 KIAA0101
KRT10 keratin 10, type I
LMNB2 lamin B2
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MELK maternal embryonic leucine zipper kinase
MYCBP MYC binding protein
NCAPG2 non-SMC condensin II complex, subunit G2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
TACC3 transforming, acidic coiled-coil containing protein 3
TAGLN transgelin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM14A transmembrane protein 14A
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZWINT ZW10 interacting kinetochore protein