BRD-A18579359_wiskostatin_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-A18579359_wiskostatin_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ANKRD10 ankyrin repeat domain 10
ARL4C ADP-ribosylation factor-like 4C
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CCNG2 cyclin G2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CLCA1 chloride channel accessory 1
COL3A1 collagen, type III, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPP4 dipeptidyl-peptidase 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FBN1 fibrillin 1
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GJA1 gap junction protein, alpha 1, 43kDa
GNPDA1 glucosamine-6-phosphate deaminase 1
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HEPH hephaestin
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LRRN3 leucine rich repeat neuronal 3
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MMP12 matrix metallopeptidase 12
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NDFIP1 Nedd4 family interacting protein 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PEG10 paternally expressed 10
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRK protein tyrosine phosphatase, receptor type, K
QPRT quinolinate phosphoribosyltransferase
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNASE4 ribonuclease, RNase A family, 4
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC38A2 solute carrier family 38, member 2
SPINK4 serine peptidase inhibitor, Kazal type 4
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I

decreased expression

Symbol Name
BZW2 basic leucine zipper and W2 domains 2
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CDC25A cell division cycle 25A
CHRDL1 chordin-like 1
CNN1 calponin 1, basic, smooth muscle
CSRP1 cysteine and glycine-rich protein 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
ENC1 ectodermal-neural cortex 1 (with BTB domain)
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
IER3 immediate early response 3
JUN jun proto-oncogene
KRT7 keratin 7, type II
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAGEA12 melanoma antigen family A12
MAP2K3 mitogen-activated protein kinase kinase 3
MOK MOK protein kinase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUP98 nucleoporin 98kDa
PALLD palladin, cytoskeletal associated protein
PI3 peptidase inhibitor 3, skin-derived
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLP1 proteolipid protein 1
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SRSF6 serine/arginine-rich splicing factor 6
TACSTD2 tumor-associated calcium signal transducer 2
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)