BRD-A18579359_wiskostatin_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-A18579359_wiskostatin_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACP5 acid phosphatase 5, tartrate resistant
ANOS1 anosmin 1
AQP3 aquaporin 3 (Gill blood group)
ARMCX1 armadillo repeat containing, X-linked 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BST2 bone marrow stromal cell antigen 2
CD52 CD52 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLGN calmegin
CLU clusterin
CTSD cathepsin D
CTSK cathepsin K
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHCR24 24-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
EBP emopamil binding protein (sterol isomerase)
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS1 fatty acid desaturase 1
FDPS farnesyl diphosphate synthase
FTH1 ferritin, heavy polypeptide 1
FZD5 frizzled class receptor 5
GJA1 gap junction protein, alpha 1, 43kDa
GNPDA1 glucosamine-6-phosphate deaminase 1
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSN gelsolin
H1F0 H1 histone family, member 0
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HEXB hexosaminidase B (beta polypeptide)
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI35 interferon-induced protein 35
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
INSIG1 insulin induced gene 1
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB5 integrin, beta 5
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LAP3 leucine aminopeptidase 3
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY6E lymphocyte antigen 6 complex, locus E
MAN1A1 mannosidase, alpha, class 1A, member 1
MDK midkine (neurite growth-promoting factor 2)
MMP2 matrix metallopeptidase 2
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
N4BP2L1 NEDD4 binding protein 2-like 1
NEU1 sialidase 1 (lysosomal sialidase)
NMU neuromedin U
NPC2 Niemann-Pick disease, type C2
NPY1R neuropeptide Y receptor Y1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLSCR1 phospholipid scramblase 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPRK protein tyrosine phosphatase, receptor type, K
PYCARD PYD and CARD domain containing
RAB29 RAB29, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
REEP1 receptor accessory protein 1
RRAGD Ras-related GTP binding D
RSAD2 radical S-adenosyl methionine domain containing 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SP110 SP110 nuclear body protein
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQLE squalene epoxidase
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
THEMIS2 thymocyte selection associated family member 2
TM7SF2 transmembrane 7 superfamily member 2
TMSB15A thymosin beta 15a
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TRIM14 tripartite motif containing 14
TRIM22 tripartite motif containing 22
TUBB6 tubulin, beta 6 class V
UBE2L6 ubiquitin-conjugating enzyme E2L 6
USP18 ubiquitin specific peptidase 18
XAF1 XIAP associated factor 1
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ADA adenosine deaminase
ADD3 adducin 3 (gamma)
ADM adrenomedullin
ANPEP alanyl (membrane) aminopeptidase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CCL2 chemokine (C-C motif) ligand 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CREB3L2 cAMP responsive element binding protein 3-like 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DLC1 DLC1 Rho GTPase activating protein
EDN1 endothelin 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
EPHA3 EPH receptor A3
F3 coagulation factor III (thromboplastin, tissue factor)
FKBP14 FK506 binding protein 14, 22 kDa
GPRC5A G protein-coupled receptor, class C, group 5, member A
HOXB7 homeobox B7
IGFBP3 insulin-like growth factor binding protein 3
LAMB1 laminin, beta 1
LEF1 lymphoid enhancer-binding factor 1
LOX lysyl oxidase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID2 nidogen 2 (osteonidogen)
NPR3 natriuretic peptide receptor 3
PCCB propionyl CoA carboxylase, beta polypeptide
PRSS21 protease, serine, 21 (testisin)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TUBB2A tubulin, beta 2A class IIa
YME1L1 YME1-like 1 ATPase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon