BRD-A18497530_EI-293_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

268 genes differentially expressed following the BRD-A18497530_EI-293_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALB albumin
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANGPTL2 angiopoietin-like 2
ANOS1 anosmin 1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APLP1 amyloid beta (A4) precursor-like protein 1
APOH apolipoprotein H (beta-2-glycoprotein I)
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C3 complement component 3
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL8 chemokine (C-C motif) ligand 8
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
COL18A1 collagen, type XVIII, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A1 collagen, type VI, alpha 1
CPE carboxypeptidase E
CTSV cathepsin V
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CYLD cylindromatosis (turban tumor syndrome)
DDHD2 DDHD domain containing 2
ECHDC2 enoyl CoA hydratase domain containing 2
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
EXPH5 exophilin 5
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FMO2 flavin containing monooxygenase 2 (non-functional)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRS2 fibroblast growth factor receptor substrate 2
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GC group-specific component (vitamin D binding protein)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPC3 glypican 3
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUSB glucuronidase, beta
HNRNPL heterogeneous nuclear ribonucleoprotein L
HP haptoglobin
HTRA1 HtrA serine peptidase 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IL1RN interleukin 1 receptor antagonist
ITM2A integral membrane protein 2A
LAMP5 lysosomal-associated membrane protein family, member 5
LCN2 lipocalin 2
LEFTY1 left-right determination factor 1
LPL lipoprotein lipase
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MAPT microtubule-associated protein tau
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MFAP2 microfibrillar-associated protein 2
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MSX1 msh homeobox 1
MXI1 MAX interactor 1, dimerization protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
OLFM1 olfactomedin 1
ORM1 orosomucoid 1
PBX3 pre-B-cell leukemia homeobox 3
PCSK6 proprotein convertase subtilisin/kexin type 6
PERP PERP, TP53 apoptosis effector
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLBD1 phospholipase B domain containing 1
PLIN1 perilipin 1
PLVAP plasmalemma vesicle associated protein
PRKCB protein kinase C, beta
PROS1 protein S (alpha)
PTPRC protein tyrosine phosphatase, receptor type, C
RBP4 retinol binding protein 4, plasma
RGS5 regulator of G-protein signaling 5
SCARB2 scavenger receptor class B, member 2
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SOX17 SRY (sex determining region Y)-box 17
SPARCL1 SPARC-like 1 (hevin)
TCF4 transcription factor 4
TF transferrin
THBD thrombomodulin
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
ZBED2 zinc finger, BED-type containing 2
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADSL adenylosuccinate lyase
AIM1 absent in melanoma 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASCC3 activating signal cointegrator 1 complex subunit 3
ATMIN ATM interactor
BAG3 BCL2-associated athanogene 3
BLCAP bladder cancer associated protein
BLVRA biliverdin reductase A
CCNG2 cyclin G2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSRP1 cysteine and glycine-rich protein 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP4 dual specificity phosphatase 4
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF3B eukaryotic translation initiation factor 3, subunit B
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF5A eukaryotic translation initiation factor 5A
EMX2 empty spiracles homeobox 2
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
FHL2 four and a half LIM domains 2
FOXO3 forkhead box O3
GDF15 growth differentiation factor 15
GLOD4 glyoxalase domain containing 4
GLRX glutaredoxin (thioltransferase)
GLRX3 glutaredoxin 3
GLS glutaminase
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GSPT2 G1 to S phase transition 2
GTPBP8 GTP-binding protein 8 (putative)
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HOXB7 homeobox B7
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
KAZN kazrin, periplakin interacting protein
KCTD12 potassium channel tetramerization domain containing 12
KRT7 keratin 7, type II
LASP1 LIM and SH3 protein 1
LDLR low density lipoprotein receptor
LIMA1 LIM domain and actin binding 1
LIMCH1 LIM and calponin homology domains 1
LRRC59 leucine rich repeat containing 59
MACF1 microtubule-actin crosslinking factor 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MED1 mediator complex subunit 1
MID1IP1 MID1 interacting protein 1
MKKS McKusick-Kaufman syndrome
MRPL12 mitochondrial ribosomal protein L12
MRPS16 mitochondrial ribosomal protein S16
MRPS35 mitochondrial ribosomal protein S35
MSMB microseminoprotein, beta-
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBPC1 myosin binding protein C, slow type
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NNMT nicotinamide N-methyltransferase
NOP56 NOP56 ribonucleoprotein
NRN1 neuritin 1
NSFL1C NSFL1 (p97) cofactor (p47)
NUP62 nucleoporin 62kDa
NXN nucleoredoxin
OAT ornithine aminotransferase
OSR2 odd-skipped related transciption factor 2
OXA1L oxidase (cytochrome c) assembly 1-like
PANK2 pantothenate kinase 2
PCGF2 polycomb group ring finger 2
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PHB prohibitin
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PNP purine nucleoside phosphorylase
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POPDC3 popeye domain containing 3
POU2AF1 POU class 2 associating factor 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRMT5 protein arginine methyltransferase 5
PROM1 prominin 1
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RNF114 ring finger protein 114
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RPS11 ribosomal protein S11
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SCAND1 SCAN domain containing 1
SEPT9 septin 9
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A2 solute carrier family 38, member 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SQSTM1 sequestosome 1
SREBF1 sterol regulatory element binding transcription factor 1
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMEM11 transmembrane protein 11
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRAPPC3 trafficking protein particle complex 3
TRIM28 tripartite motif containing 28
TRIM8 tripartite motif containing 8
TSC22D3 TSC22 domain family, member 3
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
USP22 ubiquitin specific peptidase 22
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VCP valosin containing protein
YBX3 Y box binding protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon