BRD-A18497530_EI-293_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

396 genes differentially expressed following the BRD-A18497530_EI-293_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACAA2 acetyl-CoA acyltransferase 2
ACOT13 acyl-CoA thioesterase 13
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL4 adhesion G protein-coupled receptor L4
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
ATP10B ATPase, class V, type 10B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
BLVRB biliverdin reductase B
C3ORF14 chromosome 3 open reading frame 14
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CA9 carbonic anhydrase IX
CADM1 cell adhesion molecule 1
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD38 CD38 molecule
CD52 CD52 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COMMD8 COMM domain containing 8
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CYBRD1 cytochrome b reductase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERAP1 endoplasmic reticulum aminopeptidase 1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FGG fibrinogen gamma chain
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLT1 fms-related tyrosine kinase 1
FOLR1 folate receptor 1 (adult)
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HBE1 hemoglobin, epsilon 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXD1 homeobox D1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDO1 indoleamine 2,3-dioxygenase 1
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INA internexin neuronal intermediate filament protein, alpha
ISYNA1 inositol-3-phosphate synthase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB1BP1 integrin beta 1 binding protein 1
ITM2C integral membrane protein 2C
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIAA0226L KIAA0226-like
LAMP3 lysosomal-associated membrane protein 3
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MME membrane metallo-endopeptidase
MN1 meningioma (disrupted in balanced translocation) 1
MUC16 mucin 16, cell surface associated
NPTX2 neuronal pentraxin II
NTS neurotensin
ORM1 orosomucoid 1
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4DIP phosphodiesterase 4D interacting protein
PECAM1 platelet/endothelial cell adhesion molecule 1
PLVAP plasmalemma vesicle associated protein
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSENEN presenilin enhancer gamma secretase subunit
PSPH phosphoserine phosphatase
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RHOQ ras homolog family member Q
RNASE6 ribonuclease, RNase A family, k6
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
SCG2 secretogranin II
SCG5 secretogranin V
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST18 suppression of tumorigenicity 18, zinc finger
STAB1 stabilin 1
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMSB15A thymosin beta 15a
TNNC1 troponin C type 1 (slow)
TP53I3 tumor protein p53 inducible protein 3
TP53TG1 TP53 target 1 (non-protein coding)
TPGS2 tubulin polyglutamylase complex subunit 2
TRIM2 tripartite motif containing 2
TUSC3 tumor suppressor candidate 3
UGP2 UDP-glucose pyrophosphorylase 2
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ACTN1 actinin, alpha 1
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AFF1 AF4/FMR2 family, member 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ARF6 ADP-ribosylation factor 6
ARID1A AT rich interactive domain 1A (SWI-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ARL4A ADP-ribosylation factor-like 4A
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIK BCL2-interacting killer (apoptosis-inducing)
BLCAP bladder cancer associated protein
BLM Bloom syndrome, RecQ helicase-like
BRD2 bromodomain containing 2
BRPF1 bromodomain and PHD finger containing, 1
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF169 chromosome 14 open reading frame 169
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN3 cyclin-dependent kinase inhibitor 3
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPA centromere protein A
CFAP20 cilia and flagella associated protein 20
CGRRF1 cell growth regulator with ring finger domain 1
CHD1 chromodomain helicase DNA binding protein 1
CHD7 chromodomain helicase DNA binding protein 7
CHERP calcium homeostasis endoplasmic reticulum protein
COIL coilin
CREBBP CREB binding protein
CRY1 cryptochrome circadian clock 1
CST3 cystatin C
CTPS1 CTP synthase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DCP1A decapping mRNA 1A
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP10 dual specificity phosphatase 10
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFHD2 EF-hand domain family, member D2
EHD1 EH-domain containing 1
EIF4A3 eukaryotic translation initiation factor 4A3
EIF4B eukaryotic translation initiation factor 4B
ELF1 E74-like factor 1 (ets domain transcription factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GATA2 GATA binding protein 2
GOSR1 golgi SNAP receptor complex member 1
GPATCH8 G patch domain containing 8
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOMER1 homer scaffolding protein 1
HOXA10 homeobox A10
HOXA11 homeobox A11
HOXC10 homeobox C10
HOXC6 homeobox C6
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IL6R interleukin 6 receptor
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
KYNU kynureninase
LDLR low density lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MED17 mediator complex subunit 17
MRFAP1L1 Morf4 family associated protein 1-like 1
MSH6 mutS homolog 6
MSX1 msh homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLIP myosin regulatory light chain interacting protein
N4BP2L2 NEDD4 binding protein 2-like 2
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NOP56 NOP56 ribonucleoprotein
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDLIM5 PDZ and LIM domain 5
PER2 period circadian clock 2
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PNMA1 paraneoplastic Ma antigen 1
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PTGES prostaglandin E synthase
RAB14 RAB14, member RAS oncogene family
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RBM14 RNA binding motif protein 14
RBM15 RNA binding motif protein 15
RBM25 RNA binding motif protein 25
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RHOF ras homolog family member F (in filopodia)
RIN2 Ras and Rab interactor 2
RLF rearranged L-myc fusion
RNF139 ring finger protein 139
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
RUNX3 runt-related transcription factor 3
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SAMD4A sterile alpha motif domain containing 4A
SAR1A secretion associated, Ras related GTPase 1A
SCAF8 SR-related CTD-associated factor 8
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SET SET nuclear proto-oncogene
SETD1B SET domain containing 1B
SETD5 SET domain containing 5
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A44 solute carrier family 25, member 44
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMG8 SMG8 nonsense mediated mRNA decay factor
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNW1 SNW domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPATA2 spermatogenesis associated 2
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SRRT serrate, RNA effector molecule
SRSF2 serine/arginine-rich splicing factor 2
TACC2 transforming, acidic coiled-coil containing protein 2
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDG thymine-DNA glycosylase
TDP1 tyrosyl-DNA phosphodiesterase 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE3 transducin-like enhancer of split 3
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TOP1 topoisomerase (DNA) I
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VEZF1 vascular endothelial zinc finger 1
WAC WW domain containing adaptor with coiled-coil
WDR6 WD repeat domain 6
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
YLPM1 YLP motif containing 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB11 zinc finger and BTB domain containing 11
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF330 zinc finger protein 330
ZNHIT6 zinc finger, HIT-type containing 6