BRD-A18497530_EI-293_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

404 genes differentially expressed following the BRD-A18497530_EI-293_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADAMDEC1 ADAM-like, decysin 1
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHSG alpha-2-HS-glycoprotein
AIDA axin interactor, dorsalization associated
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
ASGR2 asialoglycoprotein receptor 2
ASPN asporin
ATF3 activating transcription factor 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX4 brain expressed, X-linked 4
BHLHE40 basic helix-loop-helix family, member e40
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CEP70 centrosomal protein 70kDa
CES1 carboxylesterase 1
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLCA1 chloride channel accessory 1
COL11A1 collagen, type XI, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
DCN decorin
DIO1 deiodinase, iodothyronine, type I
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFHD1 EF-hand domain family, member D1
EIF1 eukaryotic translation initiation factor 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
F11R F11 receptor
FABP1 fatty acid binding protein 1, liver
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FPR3 formyl peptide receptor 3
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GATAD1 GATA zinc finger domain containing 1
GCG glucagon
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GSE1 Gse1 coiled-coil protein
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H1C histone cluster 1, H1c
HIST1H3H histone cluster 1, H3h
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN4 high mobility group nucleosomal binding domain 4
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
INA internexin neuronal intermediate filament protein, alpha
INHBA inhibin, beta A
INSM1 insulinoma-associated 1
ISYNA1 inositol-3-phosphate synthase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITM2C integral membrane protein 2C
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LPAR6 lysophosphatidic acid receptor 6
LPPR1 lipid phosphate phosphatase-related protein type 1
MAOA monoamine oxidase A
MMP12 matrix metallopeptidase 12
MMP19 matrix metallopeptidase 19
MMP9 matrix metallopeptidase 9
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NCAM1 neural cell adhesion molecule 1
NPTX2 neuronal pentraxin II
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRXN2 neurexin 2
NTS neurotensin
ORM1 orosomucoid 1
PBX3 pre-B-cell leukemia homeobox 3
PCBP2 poly(rC) binding protein 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDLIM3 PDZ and LIM domain 3
PID1 phosphotyrosine interaction domain containing 1
PLVAP plasmalemma vesicle associated protein
PLXNB2 plexin B2
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
PPAP2A phosphatidic acid phosphatase type 2A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTPRO protein tyrosine phosphatase, receptor type, O
PYCARD PYD and CARD domain containing
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RNF130 ring finger protein 130
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCARB2 scavenger receptor class B, member 2
SCGB1D2 secretoglobin, family 1D, member 2
SDC2 syndecan 2
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
STC1 stanniocalcin 1
STON1 stonin 1
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TCF4 transcription factor 4
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TF transferrin
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM204 transmembrane protein 204
TMSB15A thymosin beta 15a
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
UGP2 UDP-glucose pyrophosphorylase 2
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
ANXA5 annexin A5
AQP3 aquaporin 3 (Gill blood group)
ARFIP2 ADP-ribosylation factor interacting protein 2
ARMCX6 armadillo repeat containing, X-linked 6
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATG3 autophagy related 3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BIN1 bridging integrator 1
BTBD3 BTB (POZ) domain containing 3
BUB3 BUB3 mitotic checkpoint protein
C14ORF166 chromosome 14 open reading frame 166
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALML5 calmodulin-like 5
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CD164 CD164 molecule, sialomucin
CDC123 cell division cycle 123
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CGRRF1 cell growth regulator with ring finger domain 1
CLCA2 chloride channel accessory 2
CLTC clathrin, heavy chain (Hc)
COMMD4 COMM domain containing 4
COPS3 COP9 signalosome subunit 3
CORO1C coronin, actin binding protein, 1C
CRCT1 cysteine-rich C-terminal 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CUL2 cullin 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP7 dual specificity phosphatase 7
ECD ecdysoneless homolog (Drosophila)
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GLOD4 glyoxalase domain containing 4
GMDS GDP-mannose 4,6-dehydratase
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP6 insulin-like growth factor binding protein 6
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
ITGA6 integrin, alpha 6
JMJD6 jumonji domain containing 6
KAT7 K(lysine) acetyltransferase 7
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KLC1 kinesin light chain 1
KLK11 kallikrein-related peptidase 11
KLK6 kallikrein-related peptidase 6
KPNB1 karyopherin (importin) beta 1
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LAMB3 laminin, beta 3
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
MALL mal, T-cell differentiation protein-like
MAP2K3 mitogen-activated protein kinase kinase 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MAX MYC associated factor X
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED1 mediator complex subunit 1
MED6 mediator complex subunit 6
MET MET proto-oncogene, receptor tyrosine kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
MORC4 MORC family CW-type zinc finger 4
MPRIP myosin phosphatase Rho interacting protein
MRPS30 mitochondrial ribosomal protein S30
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2
NKX3-1 NK3 homeobox 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOSIP nitric oxide synthase interacting protein
NPY neuropeptide Y
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PHB prohibitin
PI3 peptidase inhibitor 3, skin-derived
PIP prolactin-induced protein
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PNMA1 paraneoplastic Ma antigen 1
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
PPAP2C phosphatidic acid phosphatase type 2C
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKCDBP protein kinase C, delta binding protein
PROM1 prominin 1
PRSS3 protease, serine, 3
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTDSS1 phosphatidylserine synthase 1
PTGES prostaglandin E synthase
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PUF60 poly-U binding splicing factor 60KDa
RAB22A RAB22A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RBM25 RNA binding motif protein 25
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RET ret proto-oncogene
RGS2 regulator of G-protein signaling 2
RNMT RNA (guanine-7-) methyltransferase
RNPS1 RNA binding protein S1, serine-rich domain
RPL27A ribosomal protein L27a
RPL36AL ribosomal protein L36a-like
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RRM1 ribonucleotide reductase M1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SACS sacsin molecular chaperone
SAR1A secretion associated, Ras related GTPase 1A
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SNW1 SNW domain containing 1
SOAT1 sterol O-acyltransferase 1
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPTBN1 spectrin, beta, non-erythrocytic 1
SRP54 signal recognition particle 54kDa
SRPX sushi-repeat containing protein, X-linked
STK17A serine/threonine kinase 17a
SUB1 SUB1 homolog (S. cerevisiae)
SUCO SUN domain containing ossification factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAM transcription factor A, mitochondrial
TFG TRK-fused gene
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TMEM5 transmembrane protein 5
TMEM97 transmembrane protein 97
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP1 topoisomerase (DNA) I
TRAPPC3 trafficking protein particle complex 3
TRIM16 tripartite motif containing 16
TSPAN8 tetraspanin 8
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein (yeast)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VGLL4 vestigial-like family member 4
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
VRK1 vaccinia related kinase 1
WDR43 WD repeat domain 43
WDR82 WD repeat domain 82
WWTR1 WW domain containing transcription regulator 1
XPO7 exportin 7
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF185 zinc finger protein 185 (LIM domain)