BRD-A18497530_EI-293_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-A18497530_EI-293_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APLP2 amyloid beta (A4) precursor-like protein 2
APOC1 apolipoprotein C-I
ASPN asporin
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C10ORF10 chromosome 10 open reading frame 10
CCL4 chemokine (C-C motif) ligand 4
CD177 CD177 molecule
CD47 CD47 molecule
CD52 CD52 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
DHRS3 dehydrogenase/reductase (SDR family) member 3
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
DUSP22 dual specificity phosphatase 22
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENOSF1 enolase superfamily member 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
HEG1 heart development protein with EGF-like domains 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LOC100505650 uncharacterized LOC100505650
LRRC15 leucine rich repeat containing 15
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MSR1 macrophage scavenger receptor 1
MXRA5 matrix-remodelling associated 5
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRTN3 proteinase 3
RGS16 regulator of G-protein signaling 16
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SFRP4 secreted frizzled-related protein 4
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SST somatostatin
ST14 suppression of tumorigenicity 14 (colon carcinoma)
THY1 Thy-1 cell surface antigen
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
XCL1 chemokine (C motif) ligand 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
ARID1A AT rich interactive domain 1A (SWI-like)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BCL10 B-cell CLL/lymphoma 10
BLCAP bladder cancer associated protein
BST2 bone marrow stromal cell antigen 2
C14ORF169 chromosome 14 open reading frame 169
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CEP170 centrosomal protein 170kDa
CEP76 centrosomal protein 76kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CHIC2 cysteine-rich hydrophobic domain 2
CHSY1 chondroitin sulfate synthase 1
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CRY1 cryptochrome circadian clock 1
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EIF4B eukaryotic translation initiation factor 4B
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FA2H fatty acid 2-hydroxylase
FAM222B family with sequence similarity 222, member B
FBXO5 F-box protein 5
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GGNBP2 gametogenetin binding protein 2
HAUS3 HAUS augmin-like complex, subunit 3
HK1 hexokinase 1
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
IGFBP4 insulin-like growth factor binding protein 4
IGHMBP2 immunoglobulin mu binding protein 2
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
KDM2A lysine (K)-specific demethylase 2A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIF1BP KIF1 binding protein
KLF4 Kruppel-like factor 4 (gut)
LMO2 LIM domain only 2 (rhombotin-like 1)
MAD2L1BP MAD2L1 binding protein
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MRPS30 mitochondrial ribosomal protein S30
NAV3 neuron navigator 3
NDC80 NDC80 kinetochore complex component
NET1 neuroepithelial cell transforming 1
NUP62 nucleoporin 62kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PELO pelota homolog (Drosophila)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PLK4 polo-like kinase 4
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPIF peptidylprolyl isomerase F
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PROM1 prominin 1
PWP1 PWP1 homolog (S. cerevisiae)
RANBP2 RAN binding protein 2
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SECISBP2L SECIS binding protein 2-like
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETX senataxin
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMG8 SMG8 nonsense mediated mRNA decay factor
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WAC WW domain containing adaptor with coiled-coil
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
ZBTB1 zinc finger and BTB domain containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF217 zinc finger protein 217