BRD-A18497530_EI-293_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

176 genes differentially expressed following the BRD-A18497530_EI-293_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AGTR1 angiotensin II receptor, type 1
ASS1 argininosuccinate synthase 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND1 cyclin D1
CFB complement factor B
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DHCR24 24-dehydrocholesterol reductase
DSP desmoplakin
EDNRA endothelin receptor type A
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6A glycoprotein M6A
GSE1 Gse1 coiled-coil protein
HIST1H1C histone cluster 1, H1c
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLK11 kallikrein-related peptidase 11
LTBP1 latent transforming growth factor beta binding protein 1
LUM lumican
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NLRP2 NLR family, pyrin domain containing 2
NMU neuromedin U
NREP neuronal regeneration related protein
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCSK6 proprotein convertase subtilisin/kexin type 6
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PRTN3 proteinase 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
REEP5 receptor accessory protein 5
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD5 stearoyl-CoA desaturase 5
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SST somatostatin
STMN2 stathmin 2
SULF1 sulfatase 1
TLR3 toll-like receptor 3
TMSB15A thymosin beta 15a
TPD52L1 tumor protein D52-like 1
TRHDE thyrotropin-releasing hormone degrading enzyme
TSPAN13 tetraspanin 13
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
AAK1 AP2 associated kinase 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADNP activity-dependent neuroprotector homeobox
ARID4B AT rich interactive domain 4B (RBP1-like)
AURKA aurora kinase A
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BIN1 bridging integrator 1
BLCAP bladder cancer associated protein
BST2 bone marrow stromal cell antigen 2
CCNA2 cyclin A2
CCR7 chemokine (C-C motif) receptor 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPA centromere protein A
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKLF chemokine-like factor
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRY1 cryptochrome circadian clock 1
CSRP1 cysteine and glycine-rich protein 1
CYTH1 cytohesin 1
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EIF4B eukaryotic translation initiation factor 4B
FASTKD5 FAST kinase domains 5
FBXO7 F-box protein 7
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GLIPR1 GLI pathogenesis-related 1
GRWD1 glutamate-rich WD repeat containing 1
GTSE1 G-2 and S-phase expressed 1
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HOXA10 homeobox A10
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KLF6 Kruppel-like factor 6
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MRPL15 mitochondrial ribosomal protein L15
MRPS2 mitochondrial ribosomal protein S2
MT1F metallothionein 1F
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDE1 nudE neurodevelopment protein 1
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PDGFA platelet-derived growth factor alpha polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PRKCA protein kinase C, alpha
RPP38 ribonuclease P/MRP 38kDa subunit
RYBP RING1 and YY1 binding protein
SMAD3 SMAD family member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THAP11 THAP domain containing 11
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOB2 transducer of ERBB2, 2
TP53BP2 tumor protein p53 binding protein 2
TRIO trio Rho guanine nucleotide exchange factor
TSC22D2 TSC22 domain family, member 2
VEZF1 vascular endothelial zinc finger 1
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
ZBTB20 zinc finger and BTB domain containing 20
ZFP36L2 ZFP36 ring finger protein-like 2