BRD-A18497530_EI-293_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

288 genes differentially expressed following the BRD-A18497530_EI-293_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ASPN asporin
ATF3 activating transcription factor 3
BLNK B-cell linker
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CADM1 cell adhesion molecule 1
CCL4 chemokine (C-C motif) ligand 4
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEP57 centrosomal protein 57kDa
CEP70 centrosomal protein 70kDa
CFB complement factor B
CHN2 chimerin 2
CKB creatine kinase, brain
CLCA1 chloride channel accessory 1
CLCA4 chloride channel accessory 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DMD dystrophin
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPCAM epithelial cell adhesion molecule
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
ESRP1 epithelial splicing regulatory protein 1
FABP1 fatty acid binding protein 1, liver
FAM69A family with sequence similarity 69, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FOXF1 forkhead box F1
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
IRF6 interferon regulatory factor 6
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KCTD20 potassium channel tetramerization domain containing 20
KIAA1462 KIAA1462
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
LUM lumican
MEIS1 Meis homeobox 1
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
MPZL2 myelin protein zero-like 2
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NR4A2 nuclear receptor subfamily 4, group A, member 2
ORM1 orosomucoid 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM3 PDZ and LIM domain 3
PLAT plasminogen activator, tissue
POSTN periostin, osteoblast specific factor
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRD protein tyrosine phosphatase, receptor type, D
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCARB2 scavenger receptor class B, member 2
SOCS2 suppressor of cytokine signaling 2
SOX17 SRY (sex determining region Y)-box 17
SPON1 spondin 1, extracellular matrix protein
STC1 stanniocalcin 1
STON1 stonin 1
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TF transferrin
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TRPS1 trichorhinophalangeal syndrome I
TSPAN12 tetraspanin 12
TYROBP TYRO protein tyrosine kinase binding protein
VGLL1 vestigial-like family member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
WSB1 WD repeat and SOCS box containing 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACOT9 acyl-CoA thioesterase 9
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTN1 actinin, alpha 1
ADGRG2 adhesion G protein-coupled receptor G2
AIM1 absent in melanoma 1
AK1 adenylate kinase 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMD1 adenosylmethionine decarboxylase 1
ANXA5 annexin A5
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARFIP2 ADP-ribosylation factor interacting protein 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
BLVRA biliverdin reductase A
BLVRB biliverdin reductase B
BTBD3 BTB (POZ) domain containing 3
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CENPB centromere protein B, 80kDa
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
COMMD4 COMM domain containing 4
CST3 cystatin C
CTDNEP1 CTD nuclear envelope phosphatase 1
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
DCK deoxycytidine kinase
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFHD2 EF-hand domain family, member D2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
FUS FUS RNA binding protein
FXYD2 FXYD domain containing ion transport regulator 2
G6PD glucose-6-phosphate dehydrogenase
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLOD4 glyoxalase domain containing 4
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTPBP8 GTP-binding protein 8 (putative)
H1FX H1 histone family, member X
HEATR1 HEAT repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HPCAL1 hippocalcin-like 1
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
KLK11 kallikrein-related peptidase 11
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LAMB1 laminin, beta 1
LASP1 LIM and SH3 protein 1
LMNA lamin A/C
LRRC59 leucine rich repeat containing 59
LY6D lymphocyte antigen 6 complex, locus D
MAGED1 melanoma antigen family D1
MALL mal, T-cell differentiation protein-like
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIA melanoma inhibitory activity
MID1IP1 MID1 interacting protein 1
MLPH melanophilin
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
NEFL neurofilament, light polypeptide
NFIB nuclear factor I/B
NKX3-1 NK3 homeobox 1
NPY1R neuropeptide Y receptor Y1
NSFL1C NSFL1 (p97) cofactor (p47)
NUP62 nucleoporin 62kDa
OXA1L oxidase (cytochrome c) assembly 1-like
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PANK2 pantothenate kinase 2
PCDH9 protocadherin 9
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PHB prohibitin
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCA protein kinase C, alpha
PRKCZ protein kinase C, zeta
PRMT1 protein arginine methyltransferase 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PUF60 poly-U binding splicing factor 60KDa
PWP1 PWP1 homolog (S. cerevisiae)
RAB5C RAB5C, member RAS oncogene family
RAE1 ribonucleic acid export 1
RAP1GAP RAP1 GTPase activating protein
RGS2 regulator of G-protein signaling 2
RNF167 ring finger protein 167
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RRBP1 ribosome binding protein 1
S100P S100 calcium binding protein P
SCAND1 SCAN domain containing 1
SEPT9 septin 9
SERBP1 SERPINE1 mRNA binding protein 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC35B1 solute carrier family 35, member B1
SMOX spermine oxidase
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SNX5 sorting nexin 5
SOX9 SRY (sex determining region Y)-box 9
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFB2M transcription factor B2, mitochondrial
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM11 transmembrane protein 11
TMEM5 transmembrane protein 5
TMEM97 transmembrane protein 97
TMX4 thioredoxin-related transmembrane protein 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC3 trafficking protein particle complex 3
TRIM16 tripartite motif containing 16
TRIM28 tripartite motif containing 28
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TUBA4A tubulin, alpha 4a
TUBB3 tubulin, beta 3 class III
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBE2Z ubiquitin-conjugating enzyme E2Z
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
USP22 ubiquitin specific peptidase 22
WWTR1 WW domain containing transcription regulator 1