BRD-A18419789_Etoposide_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-A18419789_Etoposide_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRG2 adhesion G protein-coupled receptor G2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BEX1 brain expressed, X-linked 1
BTG2 BTG family, member 2
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLCA1 chloride channel accessory 1
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CTGF connective tissue growth factor
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
EMP1 epithelial membrane protein 1
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
KRT5 keratin 5, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
NEBL nebulette
PRUNE2 prune homolog 2 (Drosophila)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS27L ribosomal protein S27-like
RTP4 receptor (chemosensory) transporter protein 4
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN1 sestrin 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
STK10 serine/threonine kinase 10
TBX3 T-box 3
TOB1 transducer of ERBB2, 1
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CCNF cyclin F
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
DBF4 DBF4 zinc finger
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FAM64A family with sequence similarity 64, member A
GTSE1 G-2 and S-phase expressed 1
HOMER1 homer scaffolding protein 1
HOXC6 homeobox C6
JADE2 jade family PHD finger 2
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KLK11 kallikrein-related peptidase 11
KRT10 keratin 10, type I
KYNU kynureninase
LBR lamin B receptor
MKI67 marker of proliferation Ki-67
MTDH metadherin
NEK2 NIMA-related kinase 2
PDLIM5 PDZ and LIM domain 5
PLK1 polo-like kinase 1
PSRC1 proline/serine-rich coiled-coil 1
QKI QKI, KH domain containing, RNA binding
SPAG5 sperm associated antigen 5
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
ZFP36L2 ZFP36 ring finger protein-like 2